What We’ve Said

What we’ve said about Asenapine

2 points from 1 episode, newest first

Also searched as Saphris, Secuado

In short

We rank asenapine B tier, though its actual efficacy might reach A. It is the only antipsychotic absorbed sublingually, so a swallowed dose gives the patient none of it.

Our take

  1. B tier, though its actual efficacy might even reach the A class, or at least sit somewhere between B and A.

    “Its actual efficacy might even reach that of the A class or at least somewhere between the B and A class”
    55:15Antipsychotic Tier List: Ranking the Best and Worst Anti-psychoticsOct 2026

How to take it

  1. It is the only sublingually absorbed antipsychotic we have. Orally dissolving tablets and films are not sublingual: they turn into liquid in the mouth and still have to be swallowed. If asenapine is swallowed, you get none of it.

    “it's the only sublingually absorbed antipsychotic that we have here. The oral dissolving tablets and films are not sublingual. They simply turn into a liquid in the mouth and then you still have to swallow it. Whereas with Saffiris, if you swallow that, you wouldn't get any”
    55:31Antipsychotic Tier List: Ranking the Best and Worst Anti-psychoticsOct 2026

From these episodes

Every point above is something said on the Psychofarm podcast, with the words as spoken and a link to the moment in the episode. It is education, not medical advice, and an episode reflects what we thought when we recorded it.

Educational content only. Everything here is what was said on the Psychofarm podcast, for clinicians. It is not medical advice and not a substitute for clinical judgment, current labeling or guidelines. An episode reflects what we thought when we recorded it, so check anything before you rely on it.