Lumateperone is basically an SRI combined with an antipsychotic: clever pharmacology, but in our opinion it causes too much agitation and cycling in true bipolar patients, and it does not come in enough doses. Once it is off patent, we might reach for it for patients with schizoaffective disorder, depressive type, who only want to take one medication.
When we reach for it
Once it is off patent, we might reach for it for patients with schizoaffective disorder, depressive type, who only want to take one medication.
“Once it's off patent, I might reach for this for patients who have schizoaffective disorder depressive type and only want to take one medication”
58:48Antipsychotic Tier List: Ranking the Best and Worst Anti-psychoticsOct 2026
Drawbacks
It is basically an SRI combined with an antipsychotic. Very clever pharmacologically, but in our opinion it causes too much agitation and cycling in true bipolar patients.
“Okay, so it's basically an SRI that's been combined with an antipsychotic. Very clever, you know, pharmacologically, but in my opinion, causes too much agitation and cycling in true bipolars”
58:30Antipsychotic Tier List: Ranking the Best and Worst Anti-psychoticsOct 2026 It does not come in enough doses: the thinking was that there is one dose and it works, and life does not work that way.
“it doesn't come enough doses. They just kind of said, oh, there's one dose and it works. Great. Well, you know, life doesn't work that way”
58:07Antipsychotic Tier List: Ranking the Best and Worst Anti-psychoticsOct 2026
From these episodes
- Antipsychotic Tier List: Ranking the Best and Worst Anti-psychoticsOct 2026 · 3 points
Every point above is something said on the Psychofarm podcast, with the words as spoken and a link to the moment in the episode. It is education, not medical advice, and an episode reflects what we thought when we recorded it.