What We’ve Said

What we’ve said about Medication adherence

22 points from 15 episodes, newest first

Also searched as adherence, nonadherence, compliance, treatment adherence, pill burden

In short

When a patient does not follow the plan, it is the clinician's problem: the alliance matters more than the exact drug, and agreement on the problem matters more than agreement on the diagnosis. Make the regimen simple (once a day, at night, every pill earning its place), take side effects seriously, and keep the patient in care even when they decline medication.

Our stance

  1. A patient's failure to follow the plan is the clinician's problem, not the patient's. You did not work out what was really going to happen once they left the office.

    “adherence is a iatrogenic phenomenon. It's up to you to figure out the regimen that you're inviting people to participate in and make it something that they want to do, not something that they don't want to do”
    30:11How to Stabilize Mood without Medications: Social Rhythm Therapy Anyone Can Use with Dr. Jim PhelpsNov 2026Guest episode
    Also said in 1 more episode
    “a patient's Failure to adhere to the game plan is the problem of a clinician, not of the patient. It's the clinician's fault when the patient doesn't adhere to a game plan because you didn't suss out what was really gonna happen when they left the office”
    59:10Dr. Jim Phelps’ Bipolar Treatment Tier List: Lessons from 30+ Years in PsychiatryJul 2026Guest episode
  2. Rapport and a patient who finds you trustworthy are more important than the nitty-gritty of which medication you pick. A strong alliance can matter more than the underlying diagnosis.

    “trust in a provider and having a good, strong therapeutic alliance is such an enormous factor and is as big if not, is bigger than what the actual underlying, can be bigger than what the underlying diagnosis is”
    58:23What is Psychosis? Look at the DSM, Common Mimics, and a Framework for the DifferentialJan 2026
    Also said in 1 more episode
    “Developing a good rapport and a patient that trusts that, you know, they feel that I'm trustworthy. We have a good relationship. That's probably infinitely more important. It's more important than the nitty gritty of the medications you pick”
    1:07:34Treating Depression: Practical Tips & Pearls for Anti-Depressant MedicationsJan 2025
  3. Taking even one medication every day is a lot harder than people give it credit for, whatever it is for.

    “even taking one medication on a daily basis is a lot harder than people give it credit for, no matter what that medication is for”
    1:00:01What Patients Should Know When Diagnosed With DepressionSep 2026

Keep the regimen simple

  1. Move all antipsychotic dosing to once a day at night, especially after a patient leaves the hospital. It makes a huge difference and even improves side effects you would not expect.

    “A lot of people don't ever learn that after a patient leaves inpatient, the best thing to do is smush it all into, you know. One time a day dosing”
    15:47Antipsychotic Tier List: Ranking the Best and Worst Anti-psychoticsOct 2026
    Also said in 1 more episode
    “A big lesson from this podcast, move all your antipsychotic dosing to once a day at nighttime. It makes a huge difference. It improves side effects that you wouldn't even expect it improves”
    Choosing Antipsychotics in Schizophrenia: Side-Effects, Maximizing Efficacy, and Finding the Right Medication | Episode 17Feb 2025
  2. Every added pill has to carry its weight. People get tired of juggling pills, and that is one reason they stop everything.

    “there's the continual risk in the background of people just going, you know, I'm tired of this label. I'm tired of these treatments. I'm just going to stop everything. That happens. And I think one of the reasons it happens is because people just get tired of juggling all those pills”
    39:45Dr. Jim Phelps’ Bipolar Treatment Tier List: Lessons from 30+ Years in PsychiatryJul 2026Guest episode
  3. For a patient who skips several doses a week but still takes it several times a week, do not be afraid of a higher aripiprazole dose: stable on 15 mg in the hospital, give 30 mg taken three or four times a week.

    “So if you have a patient that skips several of their doses every week but is still taking their medications several times a week, don't be afraid to use a higher dose Abilify. Let's say they're stable on Abilify 15 in the hospital. We'll give them Abilify 30 and they take it three or four times a week”
    36:10Antipsychotic Tier List: Ranking the Best and Worst Anti-psychoticsOct 2026
  4. Fluoxetine is nice for people who forget doses because it lasts so long.

    “We have our Prozac, which is nice for people who forget to take their medications because it lasts so long”
    29:28Treating Depression: Practical Tips & Pearls for Anti-Depressant MedicationsJan 2025
  5. The old teaching to use paroxetine in poorly adherent patients, so withdrawal reminds them to take it, is outdated. Set a phone alarm and use a pill organizer.

    “I was taught that, hey, this is something you should consider for patients of poor med adherence. They'll know as to withdraw and remember to take medication. I feel like that's very outdated. Set alarm on the phone. Use a pill organizer”
    28:43Antidepressant Tier List: Psychiatrists Rank Depression Medications for MDDMay 2026
  6. Whatever you want patients to do, lower the barriers and make it as easy as possible for them to actually do it. For something like amber lenses, it is worth buying ten pairs, keeping them in the front office and selling them back at your cost.

    “You as a clinician, when you want people to do something, make it, the lower the barriers, make it as easy as possible for them to actually do it”
    40:28How to Stabilize Mood without Medications: Social Rhythm Therapy Anyone Can Use with Dr. Jim PhelpsNov 2026Guest episode
    Also said in 1 more episode
    “It's really worth it for you as a clinician to go ahead and buy 10 pairs of the amber lenses that you want people to try and have them in your front office and then sell them back at your cost”
    39:36How to Stabilize Mood without Medications: Social Rhythm Therapy Anyone Can Use with Dr. Jim PhelpsNov 2026Guest episode

Side effects and what patients like

  1. A patient not taking a medication because of weight gain is a failed medication. If GLP-1s can prevent that, they belong in the treatment plan.

    “a patient who's not taking medication due to weight gain is a failed medication. And if GLP-1s can help prevent that, then it should be a part of our treatment plans”
    26:46Antipsychotic Tier List: Ranking the Best and Worst Anti-psychoticsOct 2026
  2. Do not assume patients hate weight-gaining drugs. Patients report really liking olanzapine and clozapine, even though we think of clozapine as a messy drug.

    “patients actually really like olanzapine. I know a lot of times we think of all medications that cause weight gain or have sexual side effects as like patients are going to hate it. Patients do report liking it”
    23:50Antipsychotic Tier List: Ranking the Best and Worst Anti-psychoticsOct 2026
    Also said in 1 more episode
    “there's studies showing that patients subjectively really like clozapine. And we think of it as this messy drug with all these problems, but patients are reporting that they really like it”
    11:13Top 10 Things to Know About ClozapineDec 2025
  3. Do not sugarcoat antipsychotics. Empathize with how annoying they can be, and stay hopeful but realistic.

    “don't sugarcoat things um and also like allow like empathize with patients for how annoying these medications can be. I think it's helpful. I think you have to stay hopeful but also stay realistic”
    Choosing Antipsychotics in Schizophrenia: Side-Effects, Maximizing Efficacy, and Finding the Right Medication | Episode 17Feb 2025

Talking to patients

  1. Always start with what the patient can see as a problem, find common ground there, and pick the medications with the fewest side effects you have access to. If they see no mental health problem at all, externalize it.

    “I think you always have to start with what's the problem for the patient. What is the patient able to see as a problem? And sometimes they see zero mental health problems. So then you'll have to externalize”
    27:53Detecting Subtle Signs of Psychosis: Assessment of Voices, Delusions, and PsychosisFeb 2026
    Also said in 1 more episode
    “you just really need to find common ground in what patients find to be a problem. And you need to pick the medications that have the least side effects that you have access to”
    1:07:48Psychosis: History, Delusions, Diagnosis, Theories, and Modern CareNov 2024
  2. When a patient is not following the plan, ask what they see as the major problem, compare it with your conceptualization, and talk openly about whether you agree and why.

    “You need to ask, what do you see as the major problem that you're having? And then you need to compare that to your conceptualization of the problem. And then you need to talk openly with the patient about, do we agree on this? Why or why not”
    54:07Lindsay Clancy Case: Biggest Misconceptions After the Mistrial Explained by a Forensic PsychiatristSep 2026
  3. Tell them plainly: my role is not to make you take medications, it is to explain what they can do and work out together whether they fit. You do not have to take them, but say when you are concerned.

    “I say, you know, my role is not to make you have medications. My role is to communicate to you the role of medications and what they can do to help you and work together to see if it's something that works for you”
    51:07Probably The Most Important Topic in Psychiatry: Therapeutic Alliance and FrameJan 2025
    Also said in 1 more episode
    “I say, you know, you don't have to take medications, but I am concerned. You know, there are some cases where I'm actually not concerned they take the medications or not because I know that psychotherapy and lifestyle changes are an equal treatment”
    53:21Probably The Most Important Topic in Psychiatry: Therapeutic Alliance and FrameJan 2025
  4. You can recommend a medication the patient disagrees with: we do not agree this is right for you, but as your doctor I am recommending it, and it will be at the pharmacy waiting for you.

    “I know we don't disagree. I know we don't agree that it's an appropriate treatment for you. But medically, as your doctor, I am recommending it. I think you should continue it because I think it is going to help you”
    28:51Detecting Subtle Signs of Psychosis: Assessment of Voices, Delusions, and PsychosisFeb 2026
    Also said in 1 more episode
    “you can say, listen, I know you disagree, but we've talked about the risks and benefits of this medication, and I think it's indicated. It'll be there at the pharmacy waiting for you”
    30:53Detecting Subtle Signs of Psychosis: Assessment of Voices, Delusions, and PsychosisFeb 2026
  5. In an uncertain or possibly prodromal case, the priority is keeping the patient in treatment, and in treatment means engaged with monitoring and follow-up, not necessarily on a medication.

    “your priority is keeping the patient in treatment and monitoring. And in treatment is not on a medication necessarily. In treatment means engaged with monitoring and follow-ups”
    46:00What is Psychosis? Look at the DSM, Common Mimics, and a Framework for the DifferentialJan 2026

Insight and agreement

  1. We would rather have a patient who says they do not have schizophrenia but takes their clozapine than one who accepts the diagnosis and refuses antipsychotics.

    “I'd rather have a patient who says, doc, I don't have schizophrenia, but I take my clozapine than a patient who says I have schizophrenia, but I hate antipsychotics and refuse to take them”
    23:49The Treatment Frame in Action: Lessons from ‘I Fell in Love with My Psychiatrist’Sep 2025
  2. Many patients with schizophrenia simply learn to go along socially. Ask why they believe they have it, and the answer is often that the doctors told them.

    “I think in the majority of cases, they simply learn to go along socially. And you can actually test this. You can say, so do you have schizophrenia? And they go like, yes. Why do you believe that? Well, that's what the doctors tell me”
    35:53Lindsay Clancy Case: Biggest Misconceptions After the Mistrial Explained by a Forensic PsychiatristSep 2026

Pitfalls

  1. Inpatient training can make it feel like the whole job is getting the patient to take medication, and that can spill into outpatient work. That is not our role.

    “first year residency is inpatient, where it feels like your entire job is get patient to take medication. And sometimes that can spill over into the future outpatient years. And that's not our role”
    51:24Probably The Most Important Topic in Psychiatry: Therapeutic Alliance and FrameJan 2025
  2. As a society we have an obligation to detect early when someone's illness leaves them unable to make a rational decision about treatment, and then to intervene, but we do not.

    “I think as a society, we have a obligation to detect early on when someone's mental illness makes them unable to actually make a rational decision about treatment. And then we have to intervene, but we don't”
    23:29Lessons from Forensic Psychiatry: Insanity Defense, Subtle Patients and CulpabilityApr 2025
  3. Paperwork can become another barrier. Ask a patient to fill out a tracking form and a missed day turns into: I forgot to fill it out yesterday, maybe I just do not want to do this.

    “But that becomes another barrier to actually just doing some of these behavior changes. This idea that you're supposed to fill out this thing. Well, I forgot to fill it out yesterday. Maybe I just don't want to do this”
    1:02:24How to Stabilize Mood without Medications: Social Rhythm Therapy Anyone Can Use with Dr. Jim PhelpsNov 2026Guest episode

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From these episodes

Every point above is something said on the Psychofarm podcast, with the words as spoken and a link to the moment in the episode. It is education, not medical advice, and an episode reflects what we thought when we recorded it.

Educational content only. Everything here is what was said on the Psychofarm podcast, for clinicians. It is not medical advice and not a substitute for clinical judgment, current labeling or guidelines. An episode reflects what we thought when we recorded it, so check anything before you rely on it.