What We’ve Said

What we’ve said about Weight gain

14 points from 6 episodes, newest first

Also searched as medication weight gain, metabolic weight gain

In short

Prevention is the best strategy: avoid weight-inducing medications when you can, weigh patients, and use metformin and GLP-1s more than we do, because a patient who stops an antipsychotic over weight gain is a failed medication. Some gain on SSRIs and antipsychotics is the treatment effect (appetite coming back), so ask about eating before blaming the drug, but true heavy gainers like olanzapine are a different story. Do not trust the minimal-weight-gain label on aripiprazole.

Prevention and treatment

  1. Prevention is the best strategy: avoid weight-gain-inducing medications.

    “the best advice is to avoid weight gain inducing medications. Avoid weight gain inducing medications. Prevention is the best strategy there. Now, don't get me wrong. Some people also begin to gain weight, even on the medication that treats depression that does not itself cause weight gain”
    56:23Treating Depression: Practical Tips & Pearls for Anti-Depressant MedicationsJan 2025
  2. A patient who stops a medication because of weight gain is a failed medication. If GLP-1s can prevent that, they belong in the plan. We have underused metformin with antipsychotics, and now GLP-1s too.

    “a patient who's not taking medication due to weight gain is a failed medication. And if GLP-1s can help prevent that, then it should be a part of our treatment plans”
    26:46Antipsychotic Tier List: Ranking the Best and Worst Anti-psychoticsOct 2026
    Also said in 1 more episode
    “we don't use Metformin enough with these medications. Now I'm thinking we don't use GLP-1s enough with these medications”
    6:04Antipsychotic Tier List: Ranking the Best and Worst Anti-psychoticsOct 2026
  3. Metformin: start low and titrate slowly because of GI distress. The dose is the same as for diabetes.

    “Don't titrate the metformin too fast. So it does cause a lot of DGI distress. So start low. Typically the dose is the same as if they had diabetes”
    30:23Top 10 Things to Know About ClozapineDec 2025
  4. Weigh your patients. In telehealth, ask them to weigh themselves regularly and report it. The gold standard is waist circumference.

    “for the telehealth people out there you can at least ask the patient to weigh themselves on a regular basis and self-report don't forget to weigh your patients now if you want to be really gold standard you're going to do waist circumference”
    Choosing Antipsychotics in Schizophrenia: Side-Effects, Maximizing Efficacy, and Finding the Right Medication | Episode 17Feb 2025

Medication or treatment effect?

  1. Some of the weight gain we see on these medications is not from the medication itself but from the treatment effect: many people do not eat when in emotional distress.

    “I think that a degree of weight gain that we see on these medications is not fully from the medication effect itself, but is actually from the treatment effect. People, many people, don't eat when they're in emotional distress”
    Choosing Antipsychotics in Schizophrenia: Side-Effects, Maximizing Efficacy, and Finding the Right Medication | Episode 17Feb 2025
  2. Population studies cannot separate direct metabolic gain from gain as a consequence of treatment, so one of us disregards the hard numbers and asks about eating before and after.

    “I personally try to disregard the hard numbers found in population studies because the population studies can't differentiate between weight gain as a direct metabolic cause of a medication and weight gain as a consequence of treatment”
    21:19Antidepressant Tier List: Psychiatrists Rank Depression Medications for MDDMay 2026
  3. In one SSRI analysis, the weight signal mostly disappeared after accounting for unhealthy eating. That is not true of heavy gainers like olanzapine.

    “one of the analyses of SSRIs showed that if you accounted for unhealthy eating, the weight gain signal mostly disappeared for SSRIs. And that's obviously not really true for crazy weight gain medications like Zyprexa”
    Choosing Antipsychotics in Schizophrenia: Side-Effects, Maximizing Efficacy, and Finding the Right Medication | Episode 17Feb 2025
  4. On average, patients may gain about five pounds over long-term treatment, and even patients working hard at it find those five pounds really tough to lose.

    “the data shows like on average, patients going to gain five pounds over a long term treatment. um i do find even patients that are trying their best implementing changes they can gain five pounds that are really tough to come off of”
    1:00:48Treating Depression: Practical Tips & Pearls for Anti-Depressant MedicationsJan 2025

Compared across drugs

  1. Aripiprazole is billed as low weight gain, but we have all seen patients gain a ton on it, mostly women in our experience.

    “We've all seen patients gain a ton of weight on aripiprazole. I do think women are affected significantly worse than men. Most of the patients that I've seen gain a ton of weight tend to be women”
    37:36Antipsychotic Tier List: Ranking the Best and Worst Anti-psychoticsOct 2026
  2. Lurasidone is metabolically pretty clean: minimal weight gain in our patients, minimal QTc prolongation, low prolactin.

    “It is metabolically pretty clean. I have had patients who have been on it and have had minimal weight gain. Minimal QTC prolongation, low prolactin”
    47:00Antipsychotic Tier List: Ranking the Best and Worst Anti-psychoticsOct 2026
  3. Lithium dosed at the minimum effective level should not cause much weight gain.

    “if you're dosing it appropriately and at the minimum effective, then you're not going to see much weight gain. But acne, unfortunately, if it happens, there's not really much you can do about it”
    28:58Mood Stabilizers for Bipolar Disorder: Lithium, Lamotrigine, Depakote & MoreJul 2026
  4. Fluoxetine is often called the most weight-neutral SSRI, but one of us sees no significant difference in practice.

    “a lot of people categorize fluoxetine as the most weight neutral. I think there was some study that in a very short term, there might have been some even weight loss. I don't see a significant difference”
    20:36Antidepressant Tier List: Psychiatrists Rank Depression Medications for MDDMay 2026
  5. By the time you need clozapine, the benefit and necessity make you a bit less worried about its metabolic risks.

    “when you're at the point that you're using clozapine, you're a little bit less worried about those other risks because of the benefit and necessity that clozapine kind of offers”
    31:46Top 10 Things to Know About ClozapineDec 2025
  6. There are not that many choices when it comes to injections, and most injections cause a lot of weight gain side effects; that is the main reason.

    “have that many choices when it comes to injections and most injections cause a lot of weight gain side effects blah blah blah that's the main reason”
    Choosing Antipsychotics in Schizophrenia: Side-Effects, Maximizing Efficacy, and Finding the Right Medication | Episode 17Feb 2025

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From these episodes

Every point above is something said on the Psychofarm podcast, with the words as spoken and a link to the moment in the episode. It is education, not medical advice, and an episode reflects what we thought when we recorded it.

Educational content only. Everything here is what was said on the Psychofarm podcast, for clinicians. It is not medical advice and not a substitute for clinical judgment, current labeling or guidelines. An episode reflects what we thought when we recorded it, so check anything before you rely on it.