What We’ve Said

What we’ve said about Brexpiprazole

2 points from 1 episode, newest first

Also searched as Rexulti

In short

We rank brexpiprazole D tier: it is essentially aripiprazole, but harder to dose in its smaller milligram increments and way more expensive. Think of it as aripiprazole with the volume turned down a little.

Compared with aripiprazole

  1. Brexpiprazole (Rexulti) is essentially aripiprazole, but harder to dose, in our opinion, because it comes in smaller milligram increments, and way more expensive.

    “Brexpiprazole or Rexulti is essentially Abilify, but harder to dose because it comes in smaller milligram increments, in my opinion, and way more expensive”
    39:55Antipsychotic Tier List: Ranking the Best and Worst Anti-psychoticsOct 2026

  2. It is aripiprazole with the volume turned down a little: it has a little less intrinsic activity.

    “It's aripiprazole with the volume turned down a little bit. So it's got a little bit less intrinsic activity than aripiprazole”
    40:36Antipsychotic Tier List: Ranking the Best and Worst Anti-psychoticsOct 2026

From these episodes

Every point above is something said on the Psychofarm podcast, with the words as spoken and a link to the moment in the episode. It is education, not medical advice, and an episode reflects what we thought when we recorded it.

Educational content only. Everything here is what was said on the Psychofarm podcast, for clinicians. It is not medical advice and not a substitute for clinical judgment, current labeling or guidelines. An episode reflects what we thought when we recorded it, so check anything before you rely on it.