What we’ve said about Quetiapine

“quetiapine is one of the only antipsychotics that kind of covers the whole gamut of bipolar. So it covers the depressive episodes. It covers the mania”

“Seroquel is approved and effective. But again, with the side effect profile, I personally don't use it. But if someone doesn't gain weight from it and they're not overstated from Seroquel, it's a good choice then”

“It's got lower risk of tardive dyskinesia than other ones, and it's pretty dang well tolerated. It's so well tolerated, it's hard to get patients off of it sometimes once they're stabilized”

“at low doses, it's a sedative at 50 milligrams and below. It's really just hitting the histamine at the 300 milligrams and below. We think about it as more of the mood symptoms. And then above 400 is when you start to get that D2 blockade”

“Well, should you really have the sedation of Seroquel for 24 hours a day? I don't think it's a good idea. So frankly, I don't think there's any good reason to do XR. And it also blunts the benefit of Seroquel's peak early on in the night to do sleep”

“You can use it in PTSD, anxiety, depression, all that stuff, but massive weight gain, appetite increase, diabetes risk, and sedation in comparison to the actual antipsychotic benefits you're getting”

“I find that even at low doses, there's considerable appetite increase in weight gain for both of those medications. So I avoid them”

“It seems like giving antipsychotics to people without schizophrenia raises the risk of tardive dyskinesia”

“We don't have to reach for quetiapine just because it works. I have a joke. Quetiapine treats every mental disorder. Okay. At some dose, quetiapine will treat every mental disorder”

“I achieve most. Most of what you want from low-dose quetiapine, Especially in a non - non-psychotic disorder, by using mirtazapine, Gabby Hinton. Gabapentin, Buspirone. Buspirone, Hydroxyzine, anything else”

“It is an antipsychotic. I don't care how much you want to tell me, oh, you know, based on reception. It's not until a XYZ dose. Not every clinician is going to follow or know the reasonable cutoffs”

“I don't think I've ever started it for sleep. I have had patients who mentioned they tried all the prior medications, they got the quetiapine. It's the only thing that works. I'm not opposed to keeping it”

“is it actually better in the long run than let's say lithium plus lamotrigine? I don't think so. But, you know, they don't study that kind of thing head to head”