What We’ve Said

What we’ve said about Benzodiazepines

32 points from 11 episodes, newest first

Also searched as benzos, Xanax, Klonopin, Valium, Ativan

In short

A benzodiazepine is a brain off switch: suppression, not treatment. It builds tolerance and dependence, impairs the learning that therapy depends on, and has no independent efficacy for depression, so we reserve it for narrow uses like catatonia, refractory sleep-wake problems, bipolar disorder and short acute crises. Inherited long-term patients need slow, careful, collaborative tapers, because withdrawal and discontinuation carry real risks.

When we reach for it

  1. We reserve benzodiazepines for refractory sleep-wake cycle disorders, catatonia and bipolar disorder. They are basically a mood stabilizer, reducing the brain's excitability, but they are a full shutdown medication. When you see catatonia, you should probably be using one.

    “I do think they are basically a mood stabilizer. They function to reduce the excitability of the brain. It's just that they're a full shutdown medication, and it's not good for those reasons. But when you see catatonia, you should probably be using it”
    59:35Mood Stabilizers for Bipolar Disorder: Lithium, Lamotrigine, Depakote & MoreJul 2026
    Also said in 1 more episode
    “Personally, I reserve the benzodiazepines for Basically, refract. Refractory The sleep -wake cycle. Cycle disorders, catatonia And, uh... And Bipolar Disorder. Disorders”
    17:47Anxiety Medications Tier List: The Best and Worst Treatments for GADJul 2026
  2. They have a role in acute decompensation in a patient whose addiction risk does not worry you, for example a one-week prescription to get through a crisis that is partly depression.

    “the Ben... benzos role is for patients with an acute decompensation that I don't have a concern about addictive risk for the patient”
    16:24Anxiety Medications Tier List: The Best and Worst Treatments for GADJul 2026
    Also said in 1 more episode
    “the Benzodiazepines can help as a short-term, one-week prescription to get over that crisis, which is partially depression”
    25:17Antidepressant Tier List: Psychiatrists Rank Depression Medications for MDDMay 2026
  3. We hate anything that causes withdrawal and physical dependence when there are other options, but that is not 'never'. Be practical: consider what is reasonable for the patient's values, goals and functioning.

    “I just really hate anything that causes withdrawal and physiological dependence for patients. I think it's an awful thing to do to somebody when there are other options, you know, um, Will I never give it? No. I remember when I was in medical school, I saw a patient who just presented for a regular medical catch up checkup”
    43:29Psychiatrist's Guide to Anxiety Medications: First Line to Last ResortJun 2025
    Also said in 1 more episode
    “we can be curious about treatment and treatment theory and treatment recommendations, but I think in the end, we should be practical too. And we need to consider what's reasonable for a patient's values, goals, and their functioning”
    45:49Psychiatrist's Guide to Anxiety Medications: First Line to Last ResortJun 2025
  4. Long-term prescribing needs at least a minimally adequate psychiatric evaluation that reaches a diagnosis, and a medical indication for a benzodiazepine in that diagnosis long term.

    “what I mean is that you've done a... at least minimally adequate psychiatric evaluation to reach a diagnosis and that there's a medical indication to prescribe that benzodiazepine for that diagnosis in the long term”
    29:01Handling Difficult Situations in Psychiatry: ADHD Evaluations, Benzo Requests, Disability Claims, and Involuntary AdmissionsOct 2025

Why we usually avoid them

  1. It is basically a brain off switch. That is suppression, not treatment, though it can be useful in some situations. It slows recovery, and it is the one case that really does match the accusation that psychiatry only suppresses symptoms.

    “It's basically a brain off switch, essentially. So that's the problem. That's not treatment. That's suppression. And that can be useful in some situations”
    18:52Anxiety Medications Tier List: The Best and Worst Treatments for GADJul 2026
    Also said in 1 more episode
    “something like a benzodiazepine is going to slow down recovery, right? Yes, you're suppressing the symptoms, but that one really does kind of match the anti-psychiatry accusations”
    8:37PTSD Medications: Integrating Pharmacotherapy, Therapy, and the Treatment Frame | Episode 22Apr 2025
  2. They are symptomatic treatments that create habits, build tolerance and stop working. They help people feel better temporarily rather than treating the underlying condition.

    “they are symptomatic treatments that create habits, build tolerance, and stop working. They're not fundamental treatments of the underlying condition, so much as they are that they're drugs that help people feel better temporarily”
    23:30Antidepressant Tier List: Psychiatrists Rank Depression Medications for MDDMay 2026
  3. Benzodiazepines, Z-drugs and alcohol are all about the same: 99 percent of the time they are not truly treating the anxiety disorder. Cannabis belongs in the same category, things that make people feel they are getting better or sleeping when they are not.

    “99% of the time you're They're not really true. Treating the anxiety disorder when you use a benzodiazepine, a Z drug, or alcohol. Frankly, all about the same in terms of their use with different levels of tolerability for different people”
    15:06Anxiety Medications Tier List: The Best and Worst Treatments for GADJul 2026
    Also said in 1 more episode
    “Alcohol, you know, Z-drugs, benzos, cannabis, I would all put in the same category as things that make people feel as if they're getting better or sleeping when they're not really necessarily getting better or sleeping”
    30:57Beyond Medications: The Best Lifestyle Treatments for Mental HealthFeb 2025
  4. Too many drawbacks: memory problems, learning problems, slower progress in psychotherapy and in healing, addiction, withdrawal and tolerance.

    “too many drawbacks, memory issues, learning problems, slows your progress. Progress in psychotherapy and healing from psychiatric disorders. Addictive. Did I already say addictive? Withdrawal problems. Tolerance, too”
    29:31Sleep Medications Treatment Tier List: Best Insomnia Medications RankedAug 2026
  5. Benzodiazepine and alcohol withdrawal is medically dangerous. People can become delirious or have life-threatening seizures.

    “Yes, benzodiazepine and alcohol withdrawal is medically dangerous, right? People can, you know, delirium, they can have life-threatening seizures as a result of withdrawal”
    27:05Handling Difficult Situations in Psychiatry: ADHD Evaluations, Benzo Requests, Disability Claims, and Involuntary AdmissionsOct 2025

Anxiety, PTSD and depression

  1. They decrease the efficacy of therapy by reducing the ability to learn new information, and the treatment for anxiety is avoiding avoidance.

    “benzodiazepines decrease the efficacy of therapy. And I feel like that's, it really decreases the ability to learn new information. So for anxiety, the treatment for anxiety is avoiding avoidance”
    18:11Anxiety Medications Tier List: The Best and Worst Treatments for GADJul 2026
  2. Anxiety is a form of activation, a higher level of psychological energy. Suppress it entirely, as a benzodiazepine does, and you slow or stop motivation itself.

    “anxiety can be interpreted as an activation right as a higher level of sort of psychological energy. And if you decrease it, remove it, or suppress it entirely as you would using a benzodiazepine, that will slow or stop motivation itself”
    3:49Psychiatrist's Guide to Anxiety Medications: First Line to Last ResortJun 2025
  3. Avoid them in PTSD: there is no clear benefit, they could worsen it, and the big problem is that they impair learning in therapy.

    “We should be avoiding benzodiazepines. And that's because there's an absence of clear benefit. It could worsen the PTSD. And the big problem is it impairs learning in therapy”
    8:10PTSD Medications: Integrating Pharmacotherapy, Therapy, and the Treatment Frame | Episode 22Apr 2025
  4. For panic, we do not use benzodiazepines or PRNs. It has to be other medications that globally lower the level of neuroticism and anxiety.

    “by the way i don't mean benzos or prms i don't use those okay it has to be other things that globally lower the level of neuroticism anxiety”
    46:02Understanding Anxiety, GAD, and Treatments of AnxietyJun 2025
  5. They have no independent efficacy in depression, even though they are given a lot, including early in SSRI starts.

    “Benzos are, I don't see any independent efficacy in depression, even though they're being given a lot. Some people like to give a benzo early on to help with the anxiety. Amphetamines. But then, yes, some people like to give a benzo or set of hypnotic early on in the initiation of SSRI”
    52:28Treating Depression: Practical Tips & Pearls for Anti-Depressant MedicationsJan 2025

Alternatives

  1. We do not do the classic benzodiazepine bridge for the first couple of weeks of an SSRI. If a patient really needs a PRN, use gabapentin or hydroxyzine.

    “So yes, I don't do the classical thing of benzos with the first couple weeks of the SRI. I don't do that. If they want a PRN, they need a PRN for some reason, I still encourage against it. I'm not going to not use it if the clinical situation is right for it. I'll use gabapentin or hydroxyzine”
    22:05Psychiatrist's Guide to Anxiety Medications: First Line to Last ResortJun 2025
  2. A short-term sleeper can just as easily be high-dose hydroxyzine, low-dose trazodone, higher-dose gabapentin, or mirtazapine if you have to.

    “I think that what you're referring to can just as easily be accomplished by high dose hydroxyzine, low dose trazodone, gabapentin at higher doses, you know, Mirtazapine if you have to”
    26:26Antidepressant Tier List: Psychiatrists Rank Depression Medications for MDDMay 2026
  3. We are always willing to give a sleeper on the first visit, because it is never one with addictive or withdrawal potential.

    “I'm always willing to give a sleeper on the first visit. And the reason is because I never really ever prescribe addictive potential withdrawal potential sleepers on the first visit or the second visit or the third or whatever”
    36:33Sleep Medications Treatment Tier List: Best Insomnia Medications RankedAug 2026

Dosing and tapering

  1. If you do use one for an anxiety disorder, make it a standing medication, not a PRN, and avoid the short-acting ones, which make addictive behavior more likely. Clonazepam or diazepam.

    “Don't use the short acting ones because that's going to make the possibility of forming addictive behavior worse. Personally, I would either do clonfin or valium”
    49:24Psychiatrist's Guide to Anxiety Medications: First Line to Last ResortJun 2025
    Also said in 1 more episode
    “You should be thinking of treating the anxiety as a standing medication and not as a PRN. It's not like, oh, take this Xanax to reduce your anxiety. There are patients who will pull you and they will desire that and you provide the psychoeducation that that's not the most effective long-term treatment of anxiety”
    49:40Psychiatrist's Guide to Anxiety Medications: First Line to Last ResortJun 2025
  2. A rule of thumb for tapering, not evidence-based: reduce or stop over a period equal to the total time on the benzodiazepine, or two years if they have been on it longer than that.

    “we're going to talk about the plan to see how we can reduce or stop the dosage over a period of time that's equivalent to the total time that they've been on the benzodiazepine or two years if they've been longer than two years. That's my general rule. It's not evidence-based”
    29:42Handling Difficult Situations in Psychiatry: ADHD Evaluations, Benzo Requests, Disability Claims, and Involuntary AdmissionsOct 2025
  3. With longstanding benzodiazepines we may have iatrogenically caused physiological change that is permanent, and some patients just have to stay on them.

    “especially when someone has been on longstanding benzos. We have basically induced iatrogenically as physicians. We have doomed them to a state of physiological change that may be permanent. They just have to be on those benzos. OK, it's not a good thing”
    47:34Psychiatrist's Guide to Anxiety Medications: First Line to Last ResortJun 2025
  4. A recent big study showed higher mortality in patients who discontinued long-term benzodiazepines. The risks of tapering are genuine and need to be considered.

    “there was like a recent big study that showed that there's a higher mortality in patients who discontinued long-term benzos. So it's, you know, there is genuine risks in tapering patients off of benzos. And those need to be genuinely considered”
    48:01Psychiatrist's Guide to Anxiety Medications: First Line to Last ResortJun 2025
  5. People who come off benzodiazepines tend to have more self-confidence, better concentration and less depression in observational studies, and PET scans show a healthier brain six or 12 months later.

    “if people come off a benzodiazepine, they tend to have greater self-confidence, better concentration, less depression, and all that's from clinical observational studies. That correlates with what we see on the PET scan, which is that the brain is healthier six or 12 months after coming off of benzodiazepine”
    5:18The Deficit Model in Psychiatry & Difficult to Treat Depression with Dr. Chris Aiken | Episode 18Mar 2025Guest episode

When a new patient asks for one

  1. Take the request not as manipulation but as coming from an innocent person who heard Xanax helps anxiety, and calmly lay out why it will not help long term and why you will not go that route.

    “I take them not as trying to manipulate me, not as trying to get this drug. I take them as an innocent person who heard that Xanax is helpful for anxiety and calmly lay out my reasoning as to why I don't think it'll be helpful long term and why we won't be going that route”
    52:09Psychiatrist's Guide to Anxiety Medications: First Line to Last ResortJun 2025
  2. Confirm on your state's controlled substance record that they really have been getting it.

    “I will want to confirm in some fashion that they have been getting the controlled substance on my state record. I think every state now has a record of controlled substance prescriptions that you can look at”
    27:38Handling Difficult Situations in Psychiatry: ADHD Evaluations, Benzo Requests, Disability Claims, and Involuntary AdmissionsOct 2025
  3. Even under the urgency of apparent withdrawal, do not agree to be one stop in a series of doctors giving urgent benzodiazepine prescriptions.

    “You should not, even under the urgency of apparent medical withdrawal, agree to be the stopover in a series of doctors that a patient is going to for urgent benzodiazepine prescriptions”
    26:08Handling Difficult Situations in Psychiatry: ADHD Evaluations, Benzo Requests, Disability Claims, and Involuntary AdmissionsOct 2025
  4. Ask them to commit today to treatment with you and to a medically safe tapering plan.

    “You need to commit today to treatment with me and we need to commit to a with a tapering plan, basically a withdrawal plan that is medically safe”
    28:18Handling Difficult Situations in Psychiatry: ADHD Evaluations, Benzo Requests, Disability Claims, and Involuntary AdmissionsOct 2025
  5. One compromise: pick a date together in the next few weeks to get to a medical detox center, and give enough medication to last until then.

    “let's pick a date together in the next few weeks where we can get you to a medical detox center. And I'm going to give enough medication to last until then”
    31:19Handling Difficult Situations in Psychiatry: ADHD Evaluations, Benzo Requests, Disability Claims, and Involuntary AdmissionsOct 2025
  6. Tell them everyone can see the controlled substance record, so if they do not come back and you see the pattern, you will know they did not agree with the plan.

    “we all have access to this controlled substance record. And so if I see this happening and you don't come back, then I'm going to know that you're not really agreeing with me about how we're supposed to treat this”
    33:54Handling Difficult Situations in Psychiatry: ADHD Evaluations, Benzo Requests, Disability Claims, and Involuntary AdmissionsOct 2025
  7. Usually it devolves into yelling and firing well before that, and then you simply do not prescribe. It is probably the number one reason new patients fire their psychiatrist.

    “Usually, it devolves into yelling and firing. way before that, you know, and it's what you do. And then you just essentially don't prescribe it”
    35:24Handling Difficult Situations in Psychiatry: ADHD Evaluations, Benzo Requests, Disability Claims, and Involuntary AdmissionsOct 2025
    Also said in 1 more episode
    “this is probably the number one cause of me being fired as a psychiatrist for new patients”
    25:04Handling Difficult Situations in Psychiatry: ADHD Evaluations, Benzo Requests, Disability Claims, and Involuntary AdmissionsOct 2025

Talking to patients

  1. Explain plainly: if I prescribed these long term, I would be hurting you, preventing you from getting better.

    “You have to explain to the patient, like, I'm hurting you if I were to prescribe these things long term. I'm preventing you from getting better”
    18:35Anxiety Medications Tier List: The Best and Worst Treatments for GADJul 2026
  2. Before starting one, spell it out: a controlled substance that causes addiction, withdrawal, executive function and memory problems and sedation, and probably slows progress in psychotherapy. And if you change doctors, the next one may not continue it.

    “You're going to be on a controlled substance that causes addiction, withdrawal, executive functioning problems, memory problems, sedation, and it probably slows your ability to improve yourself in the psychotherapy as well. And I might be happy to give this to you, but I can't say that if you have to change doctors”
    48:38Psychiatrist's Guide to Anxiety Medications: First Line to Last ResortJun 2025
  3. The lowest-risk anxious patient for habituation is the medication hater: strong placebo effects and a negative emotional relationship with medications.

    “A certain personality type that tends to have an anxiety disorder is probably the lowest risk for addiction habituation with benzodiazepines. It's the medication hater. It's the person who does have strong placebo effect and negative emotional relationship with medications, right”
    21:22Psychiatrist's Guide to Anxiety Medications: First Line to Last ResortJun 2025

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Every point above is something said on the Psychofarm podcast, with the words as spoken and a link to the moment in the episode. It is education, not medical advice, and an episode reflects what we thought when we recorded it.

Educational content only. Everything here is what was said on the Psychofarm podcast, for clinicians. It is not medical advice and not a substitute for clinical judgment, current labeling or guidelines. An episode reflects what we thought when we recorded it, so check anything before you rely on it.