What We’ve Said

What we’ve said about Anxiety

53 points from 11 episodes, newest first

Also searched as anxiety disorders, worry

In short

Anxiety is more often a signal of something else than a thing in itself, so do not stop at the word: find the source, treat the diagnosis rather than the symptom, and expect a formulation to matter more than a DSM label. Prefer therapy, mindfulness and scheduled medications that lower overall anxiety over PRNs and benzodiazepines, which teach the brain it needs something external and undo the lesson that you can handle it.

What it is

  1. Anxiety is more often a signal or experience stemming from other things than its own thing. Almost every primary emotion can be converted into anxiety: apple, banana and strawberry are fruits, but fruit salad is not, and anxiety is the fruit salad. So look for the source.

    “anxiety is more often than not a signal or an experience associated with or stemming from other things rather than its own thing. But most people tend to think of anxiety as a thing in itself”
    2:53Understanding Anxiety, GAD, and Treatments of AnxietyJun 2025
    Also said in 2 more episodes
    “there are some thinkers, and I agree with those thinkers, that will say almost every primary emotion can be converted into anxiety. This is why I say look for the source of anxiety”
    29:14Understanding Anxiety, GAD, and Treatments of AnxietyJun 2025
    “Apple's a fruit. Banana is a fruit. Strawberry is a fruit. but fruit salad is not a fruit um and here anxiety would be the the fruit salad”
    30:05Understanding Anxiety, GAD, and Treatments of AnxietyJun 2025
  2. Anxiety disorders are not like schizophrenia or bipolar disorder, with a separate medical reality. They are real, known clinical types, but they do not necessarily share an underlying cause.

    “a lot of people act like a anxiety disorder is its own thing, like a schizophrenia or a bipolar disorder, something like that, where there's sort of a separate medical reality to it”
    17:47Understanding Anxiety, GAD, and Treatments of AnxietyJun 2025
    Also said in 1 more episode
    “These are all real known clinical types, but do they reflect the same underlying cause? Not necessarily”
    27:39Understanding Anxiety, GAD, and Treatments of AnxietyJun 2025
  3. PTSD and OCD were anxiety disorders in DSM-III and IV and are now separate chapters, and we agree with that separation.

    “In DSM 3 and 4, PTSD and other related disorders and OCD were considered anxiety disorders. They are now considered separate chapters, and I actually agree with that separation”
    20:08Understanding Anxiety, GAD, and Treatments of AnxietyJun 2025
  4. A simple model: the amygdala is the smoke detector and the prefrontal cortex is the watchtower. Fear is bottom up: it starts with a threat and the alarm, and the thinking comes afterward.

    “the smoke detector is the amygdala. That's the bottom part, and I'll explain that in a second. The watchtower is the prefrontal cortex, and that's the top part”
    7:17Understanding Anxiety, GAD, and Treatments of AnxietyJun 2025
    Also said in 1 more episode
    “fear is bottom up. It starts with the alarm, and then it gets the thinker thinking afterwards, and it starts with a threat”
    10:02Understanding Anxiety, GAD, and Treatments of AnxietyJun 2025
  5. Worry is the cognitive component. Worry is in the mind; anxiety is in the mind and throughout the body.

    “Worry to me is the cognitive component of anxiety. It's just the, so worry is in the mind, anxiety is in the mind and throughout the body”
    14:59Understanding Anxiety, GAD, and Treatments of AnxietyJun 2025
  6. There is a sweet spot: too little arousal and you do not perform well, too much and you do not either. The same goes for psychotherapy, where the patient needs an optimal level of activation, neither over- nor under-regulated.

    “there's a sweet spot in that if you have too little arousal, you're not going to perform well. If you have too much arousal, you're not going to perform well”
    4:59Understanding Anxiety, GAD, and Treatments of AnxietyJun 2025
    Also said in 1 more episode
    “in a psychotherapy, the patient needs to be at an optimal level of activation, not over-regulated, not under-regulated for optimal treatment”
    6:21Understanding Anxiety, GAD, and Treatments of AnxietyJun 2025
  7. There are two anxiety centers in the brain: Panksepp's fear system, and the panic-grief system, which is the attachment system.

    “there are two different anxiety centers in the brain. One of them is Panksepp's fear system, and the other is what he calls the panic-grief system, which is the attachment system”
    48:41Nancy McWilliams on Psychoanalytic Diagnoses, Part 1: Personality, Defenses, Themes, Paranoid PersonalityNov 2024Guest episode
  8. Anxiety can be seen as activation, a higher level of psychological energy. Remove or suppress it entirely, as a benzodiazepine does, and you slow or stop motivation itself.

    “anxiety can be interpreted as an activation right as a higher level of sort of psychological energy. And if you decrease it, remove it, or suppress it entirely as you would using a benzodiazepine, that will slow or stop motivation itself”
    3:49Psychiatrist's Guide to Anxiety Medications: First Line to Last ResortJun 2025

How we assess it

  1. Do not stop at calling it anxiety. Find the source, whether external, internal or an interaction of both. There are many sources, so do a thorough assessment before making recommendations.

    “don't just stop at calling it anxiety find the source of the anxiety whether it's external internal or a combination interaction between external and internal factors”
    21:46Understanding Anxiety, GAD, and Treatments of AnxietyJun 2025
    Also said in 1 more episode
    “anxiety is complicated. It might not be its own thing in most cases, that there are many different sources for anxiety and that you got to do a thorough assessment before you can make reasonable recommendations”
    56:24Understanding Anxiety, GAD, and Treatments of AnxietyJun 2025
  2. Look at the diagnosis first and treat the diagnosis, not the symptom. Anxiety is not something to manage with medications regardless of the cause.

    “look at the diagnosis first and treat the diagnosis. Don't treat the symptom. You can't treat anxiety as this thing that we're supposed to manage with medications regardless of the cause”
    56:59Understanding Anxiety, GAD, and Treatments of AnxietyJun 2025
  3. With anxiety in particular, a DSM diagnosis may not cut it. You may need a full psychotherapy-type formulation to understand the patient's situation.

    “with anxiety in particular, DSM diagnosis may not cut it, right? You might have to go on to a full-on psychotherapy-type formulation to really understand the patient's situation”
    57:25Understanding Anxiety, GAD, and Treatments of AnxietyJun 2025
  4. Ask patients to avoid clinical terms, which mean different things to different people. When you say your anxiety increased, what did you actually experience?

    “I go, let's try our best to not use clinical terms because it can mean different things to different people. When you say you had an increased anxiety, what did you experience? What are you referring to”
    23:10Psychiatric Technique for Diagnostic Interviewing and Therapy: 6 Mantras Every Clinician Should KnowApr 2026
  5. For medication management, first assess fully for other physiological and medical causes, especially substances.

    “When we talk about medication management, assess entirely for other physiological and medical causes, especially substances of anxiety”
    1:00:24Psychiatrist's Guide to Anxiety Medications: First Line to Last ResortJun 2025
  6. A quick map by what is feared: GAD, many topics; panic disorder, the panic attack; phobia, a specific stimulus; agoraphobia, being trapped or helpless in public.

    “Generalized anxiety is fear of multiple topics. I think a panic disorder is fear of a panic attack. Phobia is a fear of a specific stimulus. Agoraphobia is a fear of being trapped or helpless related to being in public”
    23:23Understanding Anxiety, GAD, and Treatments of AnxietyJun 2025
  7. GAD is probably its own disorder, but the criteria are too loose and too many people are diagnosed. They should be tightened to capture a smaller share of the population.

    “I do think that GAD is its own disorder in a sense, but that the criteria is too loose and that too many people are being diagnosed with it when we should probably tighten up the criteria and capture a smaller proportion of the population”
    1:59Psychiatrist's Guide to Anxiety Medications: First Line to Last ResortJun 2025

What it gets confused with

  1. 'Too much anxiety' can turn out to be a trauma and stressor-related disorder: new symptoms from actively living in an abusive environment, not trait anxiety.

    “if you looked at his history, it was because he was actively living in an abusive environment and that the symptoms that he was having, new onset, were not from a trait anxiety, but were basically a trauma stressor related disorder”
    54:11Understanding Anxiety, GAD, and Treatments of AnxietyJun 2025
  2. Apparent ADHD that shows up later in life is most often a mood and anxiety problem, sometimes a diagnosable depression, bipolar or anxiety disorder but often a fuzzy mix: a self-punitive or anxious response to not doing well after something changed.

    “probably the biggest thing I see is that It's some kind of mood and anxiety problem, sometimes diagnosable as a major depression, a bipolar, or a primary anxiety disorder, but often just a fuzzy mix, right? Maladaptive, self-punitive, or anxious response to not doing so well”
    43:51ADHD Again, But Juicier: Unpacking Misdiagnosis, Medication Overuse, and Cultural TrendsOct 2024
    Also said in 1 more episode
    “What I tend to see most frequently is that people who are presenting, especially later in their lives with apparent ADHD, that is inattention problems, executive functioning problems, is that Something has happened in their lives, in their minds, or in both”
    37:09ADHD Again, But Juicier: Unpacking Misdiagnosis, Medication Overuse, and Cultural TrendsOct 2024
  3. Online prescriber threads answer a short anxiety post with hundreds of medication tips ('just a touch of aripiprazole') and nobody asking what is going on in the person's life.

    “just hundreds of people being, you know, I really liked, you know, just a touch of Abilify. Is no one going to ask what's going on in this woman's life”
    55:56Understanding Anxiety, GAD, and Treatments of AnxietyJun 2025

Treatment approach

  1. Anxiety can be approached through several models: biological (just using medications), cognitive (addressing thought distortions) and exposure (addressing avoidance behavior).

    “The first is the biological model that's just using medications. Second is the cognitive model that's addressing thought distortions. The third is the exposure model that's addressing avoidance behavior”
    31:20Understanding Anxiety, GAD, and Treatments of AnxietyJun 2025
  2. Another grouping by clinical type: GAD proper, dead-loop avoidance problems like panic disorder and agoraphobia, specific fear problems like phobias, and developmental-relational problems.

    “uh gad proper um dead loop avoidance problems such as panic disorder and agoraphobia and then specific fear problems such as the specific phobias and then developmental rate relational problems”
    33:07Understanding Anxiety, GAD, and Treatments of AnxietyJun 2025
  3. If the source is developmental, a matter of how someone relates to other people and to themselves, then the only solution is developmental.

    “If the source of the problem is developmental, which is a process of relating with other people and yourself, then the only solution is going to be developmental”
    52:12Understanding Anxiety, GAD, and Treatments of AnxietyJun 2025
  4. If a patient can engage in therapy, therapy comes before medications. Medications go first when they are too symptomatic to engage, or out of respect for patient autonomy.

    “If a patient can engage in therapy, I think that they should be engaged in therapy before medications. When do I use medications first? First, if they're too symptomatic, that they're not able to engage in therapy. And second, patient autonomy”
    8:05Psychiatrist's Guide to Anxiety Medications: First Line to Last ResortJun 2025
  5. Mild anxiety can forgo treatment entirely.

    “mild anxiety can forego treatment entirely. That means that back in the old days, if you came in, people who were seeing psychiatrists were bedridden, were acutely catatonic. Nowadays, it's not uncommon for me to get patients that I finish the assessment and I go”
    7:27Psychiatrist's Guide to Anxiety Medications: First Line to Last ResortJun 2025
  6. A huge part of treatment is avoiding avoidance. Signing paperwork for permanent remote work, for example, promotes the avoidance.

    “a huge part of that is avoiding avoidance. And by signing that paperwork, you're promoting the avoidance”
    1:03:58Disability Claims 101 for Psychiatrists: Programs, Pitfalls, and Practical StepsDec 2025
  7. A request for an emotional support animal is usually a signal of an important area of impairment that should be treated, and an opening to talk about it.

    “usually the request is a signal. for a important area of impairment, pathology that should be treated. And that's a opportunity to talk about that with the patient”
    1:04:56Disability Claims 101 for Psychiatrists: Programs, Pitfalls, and Practical StepsDec 2025

Therapy and skills

  1. If the patient can tolerate and engage with it, mindfulness practice is the ultimate treatment and a fast track to lowering and managing anxiety long term. If that is not working, CBT-style treatment is quite helpful.

    “I think that's the ultimate treatment. If you can tolerate and engage with mindfulness practice, that's going to be a fast track to lowering and managing anxiety in the long term. And if that's not working for you, a CBT style Treatment for anxiety is quite helpful”
    57:39Psychiatrist's Guide to Anxiety Medications: First Line to Last ResortJun 2025
  2. Turning attention to neutral parts of the present moment helps ruminators and panickers, because the cause of the fear is often not what is happening in front of them. It moves them from inward to outward focus.

    “And then also essentially combating ruminations, worries, anxiety, and inward focus by going into outward focus. Both of these can be achieved by a more consistent mindfulness practice”
    17:53Mindfulness in Psychiatry: How to Teach It as a Clinical Treatment SkillMay 2026
    Also said in 1 more episode
    “the ability to turn attention to neutral aspects of the present moment can be very helpful for ruminators and panickers because a lot of the time the cause of the fear or panic is not what is going on outside of you in real life in the present moment”
    41:21Understanding Anxiety, GAD, and Treatments of AnxietyJun 2025
  3. Pull out the emotion wheel and find the underlying emotion. Many people filter their whole emotional world through anxious or angry. Naming rejection or loneliness instead gives them emotions that are productive and can be acted on.

    “Pull out that emotion wheel, teach them to bring out the emotion wheel and try to find the underlying emotion. There's a lot of people who - They filter their emotional world through, oh I'm anxious or angry”
    22:20Anxiety Medications Tier List: The Best and Worst Treatments for GADJul 2026
    Also said in 1 more episode
    “the goal was to take out the emotion wheel and instead of saying like i'm experiencing anxiety we identified that they were experiencing rejection that they were experiencing loneliness um which are emotions that are productive and that can be acted on”
    50:59Understanding Anxiety, GAD, and Treatments of AnxietyJun 2025
  4. When exercise brings big improvement in anxiety, it may not be the exercise itself but that people are inadvertently entering flow states and practicing mindfulness.

    “I think when you see that level of improvement, it's not the exercise. It's because they're inadvertently entering flow states. They're inadvertently practicing mindfulness”
    41:12Anxiety Medications Tier List: The Best and Worst Treatments for GADJul 2026
  5. Religion or spirituality, belief in things bigger than ourselves, does an amazing thing for quelling anxiety.

    “I do think any sort of religion or spirituality, belief in things bigger than ourselves, does an amazing thing for quelling anxiety”
    10:20Anxiety Medications Tier List: The Best and Worst Treatments for GADJul 2026

Why we avoid PRNs

  1. PRNs are for temporary use, and most of the time they get in the way of appropriate treatment. With a PRN you are forcing the safety signal to be a medication. Think in scheduled medications instead.

    “They're for temper. Temporary use, and most of the time they actually get in the way of appropriate treatment. So, uh... Most of the things we're going to be And that's what we're talking about today. Today are going to be about scheduled medications”
    5:30Anxiety Medications Tier List: The Best and Worst Treatments for GADJul 2026
    Also said in 1 more episode
    “PRNs are not a good treatment plan. Okay. What you are really doing with a PRN for the vast majority of cases is that you are adding a safety signal to that can be used and you're forcing the safety signal to be a medication”
    13:42Psychiatrist's Guide to Anxiety Medications: First Line to Last ResortJun 2025
  2. Anxiety is an overactive threat detection system. Rely on a medication to quell it and you tell your brain you need something external, which undercuts the key lesson: trusting that you will be OK and can handle it.

    “Anxiety, Theory. Theoretically, is an overactive threat detection system. And if you rely on a medication And to quell that. That anxiety, you're telling your brain that I need something external to fix this anxiety”
    6:50Anxiety Medications Tier List: The Best and Worst Treatments for GADJul 2026
    Also said in 1 more episode
    “if you give a PRN, you're going to reduce the important teaching point. And I think the important teaching point for improving with anxiety is being able to trust that you'll be okay and trust that you're able to handle something”
    15:02Psychiatrist's Guide to Anxiety Medications: First Line to Last ResortJun 2025
  3. Without a PRN, people develop other coping skills: going outside for a bit, a breathing practice.

    “If you don't use a PRN, then you start to develop other coping skills. You know, like I personally, if I'm starting to feel increased anxiety, I need to go outside for a little bit. I do like to do a little bit of a Wim Hof”
    15:29Psychiatrist's Guide to Anxiety Medications: First Line to Last ResortJun 2025

Medications

  1. The usual order: an SSRI, then another SSRI, then augmenting with buspirone or gabapentin. If they are still unresponsive, go by patient characteristics, such as mirtazapine for a lot of sleep trouble.

    “Typically, I use an SSRI. That doesn't work. I'll switch to another SSRI. We're talking augmenting agents, considering buspirone or gabapentin. If their patient's still unresponsive to, you know, a bunch of these things, you can start kind of going off patient characteristics. If there's a lot of sleep issues, I'll consider mirtazapine”
    36:03Psychiatrist's Guide to Anxiety Medications: First Line to Last ResortJun 2025
  2. When the picture is likely trauma or personality and the diagnosis is still undifferentiated, start with smaller things (gabapentin, hydroxyzine, buspirone, propranolol) rather than serotonin-based medications, because of the risk of agitating an unrecognized bipolar disorder.

    “Not SSRIs, you know, not necessarily serotonin-based medications primary because of the risk of agitating bipolar disorders because in undifferentiated patient, we don't know which is which, but just smaller things, you know. your gabapentin hydroxyzine your uh buspirone uh propranolol”
    28:35What is Psychosis? Look at the DSM, Common Mimics, and a Framework for the DifferentialJan 2026
  3. Patients with very high anxiety, or a little bipolarity, can react to fast titration of a drug like escitalopram.

    “the people who might have a little bipolarity, even if they'll never have a real bipolar disorder or have very high levels of anxiety, then yeah, going too quickly on the medication like Lexapro can definitely, uh, cause some reactions there”
    21:50Treating Depression: Practical Tips & Pearls for Anti-Depressant MedicationsJan 2025
  4. Buspirone: start at a minimum of 15 mg in the morning and 15 mg at night. If it makes them very sedated, cut the morning dose in half or stop it.

    “you want to start at minimum 15 in the morning, 15 at night. That's the starter dose. Now, what I do say to patients is that if this happens to make you very sedated, then cut the morning dose in half or stop it”
    19:44Psychiatrist's Guide to Anxiety Medications: First Line to Last ResortJun 2025
  5. Gabapentin is more effective at 900 to 3,600 mg a day. Its absorption is nonlinear, so much less is absorbed at higher doses: cap a single dose around 1,200 mg and split the rest. We do not give a lot of it for anxiety, but we are not opposed.

    “Typically, it's more effective at the like 900 to 3,600 milligrams per day range. And It's important to remember that gabapentin has, quote unquote, nonlinear pharmacokinetics, which is just a fancy way of saying that like, you know, 2400 sounds like a mega dose, but significantly less is absorbed as you get to the higher doses”
    24:54Psychiatrist's Guide to Anxiety Medications: First Line to Last ResortJun 2025
    Also said in 1 more episode
    “I try to cap it at 1,200 personally. I feel like, what are you doing at that point? Just separate it out into a different dose. Do I give a lot of gabapentin for anxiety disorder? No, but I'm not opposed to it”
    25:51Psychiatrist's Guide to Anxiety Medications: First Line to Last ResortJun 2025
  6. Hydroxyzine is not a favorite, but it is low risk and some people like it. The dividing line is sedation: some get far too sedated.

    “I don't love hydroxyzine, but I will hand it out because it's a low-risk medication, generally speaking. Some people just seem to like it. I think the main dividing line is how sedated you get on it. Some people just get way too sedated on hydroxyzine”
    28:47Psychiatrist's Guide to Anxiety Medications: First Line to Last ResortJun 2025
  7. Propranolol needs some evidence of an upregulated fight-or-flight system. It is used for trauma disorders and for akathisia, being low risk and effective.

    “I want to see some kind of evidence of upregulation of the fight or flight system. So I do use it for trauma disorders, and I certainly use it for echithesia because it's low risk and effective. I'm not opposed to using it if anyone wants to try it”
    32:23Psychiatrist's Guide to Anxiety Medications: First Line to Last ResortJun 2025
  8. Bupropion helps anxiety for some patients but worsens it for a lot of others, and for many anxious depressed patients sertraline will be much more effective. Patients with OCD, PTSD or anxiety on bupropion often get better when you pull it.

    “I've just seen so many times patients with OCD, PTSD, anxiety on bupropion. You pull it off and they get better”
    35:46Anxiety Medications Tier List: The Best and Worst Treatments for GADJul 2026
    Also said in 1 more episode
    “There are patients with depression that I'm telling you that Zoloft will be a much more effective medication for you. As you mentioned, with anxiety. Yes, it does help anxiety for some patients, but it does worsen anxiety for a lot of other patients”
    51:50Antidepressant Tier List: Psychiatrists Rank Depression Medications for MDDMay 2026
  9. Another view: bupropion is effective in anxiety disorders, per the data, if the patient can get over the hump of the more activating, anxiety-provoking start. If you trial it, have them take it first on a weekend or when they have nothing to do.

    “if we are going to trial it, I recommend they try it for the first time on a weekend or something or when they have nothing to do”
    53:28Antidepressant Tier List: Psychiatrists Rank Depression Medications for MDDMay 2026
    Also said in 1 more episode
    “Wellbutrin is actually effective in anxiety disorders, but you have to get over the hump of the initial part. It's more activating and anxiety-provoking for anxious people at the beginning, but if they can tolerate it and stay on it, the data does show that it's effective in anxiety disorders, and in my experience, it is”
    36:48Psychiatrist's Guide to Anxiety Medications: First Line to Last ResortJun 2025
  10. For primary anxiety not responding to SSRIs and SNRIs, the traditional answer is tricyclics. For experienced or well-supervised clinicians at the end of the road, consider an MAOI.

    “that is a method of last resort that I even placed beyond, and I will try before that, the tricyclics. And that's actually the traditional answer to what to do with someone who is having a primary anxiety disorder, who's not responding to your SSRIs, SNRs. You should be using tricyclics”
    37:25Psychiatrist's Guide to Anxiety Medications: First Line to Last ResortJun 2025
    Also said in 1 more episode
    “don't be shy if you are an experienced or under good supervision clinician and you're reaching the end of the road of pharmacological agents for anxiety for a patient. You can consider an MAOI. Same thing for your depression patients, right”
    41:14Psychiatrist's Guide to Anxiety Medications: First Line to Last ResortJun 2025
  11. We do not use antipsychotic augmentation for primary anxiety: the evidence is insufficient. OCD, separated from the anxiety disorders since DSM-5, is a different matter.

    “I don't do it at all for only anxiety. I think that we have insufficient to know evidence basis for antipsychotic augmentation of primary anxiety. Again, this is not counting OCD, which has been separated from the anxiety disorders since DSM-5”
    53:35Psychiatrist's Guide to Anxiety Medications: First Line to Last ResortJun 2025
  12. We hate anything that causes withdrawal and physiological dependence when there are other options, but that does not mean never giving a benzodiazepine.

    “I just really hate anything that causes withdrawal and physiological dependence for patients. I think it's an awful thing to do to somebody when there are other options, you know, um, Will I never give it? No. I remember when I was in medical school, I saw a patient who just presented for a regular medical catch up checkup”
    43:29Psychiatrist's Guide to Anxiety Medications: First Line to Last ResortJun 2025
  13. Paroxetine is not better for anxiety than the others. Anxious people tend to worsen at night, so anything sleepy helps, and that can be a little gabapentin.

    “I don't see it as any better than the others. It's more that anxiety, people with anxiety disorders tend to have worsening anxiety and ruminations at night. So if you give them something that makes them sleepy, they're going to help them with that. And it does not have to be Paxil. It can be a little gabapentin, for example”
    30:35Treating Depression: Practical Tips & Pearls for Anti-Depressant MedicationsJan 2025
  14. Lavender: people love it for the first few months, then it poops out, usually with no significant difference by six months. Kava is mildly habit forming and carries a liver toxicity risk.

    “people love it for the first few months and then it kind of poops out. So usually by like six months, they don't see any sort of significant difference”
    58:44Anxiety Medications Tier List: The Best and Worst Treatments for GADJul 2026
    Also said in 1 more episode
    “I think it's m - mildly habit forming. The risk And that's what I think is... liver toxicity”
    57:08Anxiety Medications Tier List: The Best and Worst Treatments for GADJul 2026

Caffeine and stimulants

  1. People coming to a psychiatrist for anxiety should drink at most one cup of coffee. Cutting caffeine is low-hanging fruit: people have very little awareness of how much it feeds their anxiety, and it makes a huge difference.

    “People who are coming to a psychiatrist for anxiety should be drinking at most one cup of coffee”
    38:31Anxiety Medications Tier List: The Best and Worst Treatments for GADJul 2026
    Also said in 1 more episode
    “That is a low hanging, super easy thing. Patients often have no, very little, not patients, people have very little awareness of how much anxiety, how much caffeine can impact their anxiety and reduce, like, you know, it's very hard to get someone to reduce their triple espressos from Starbucks. It makes a huge difference”
    1:00:40Psychiatrist's Guide to Anxiety Medications: First Line to Last ResortJun 2025
  2. In proper ADHD, a stimulant's reduction of psychological anxiety far outweighs the minor physiological anxiety it adds.

    “if you're treating a proper ADHD, the psychological anxiety reduction far outweighs It's the minor physiological. Physiological anxiety”
    37:53Anxiety Medications Tier List: The Best and Worst Treatments for GADJul 2026

Talking to patients

  1. Get used to accepting suffering. There is a minimum level of suffering and anxiety you have to live with, and if you accept it, you will not make it worse.

    “I'd like you to get used to accepting suffering. There's a minimum level of suffering and anxiety that you have to live with. And if you accept that, you won't make it worse”
    16:44Psychiatrist's Guide to Anxiety Medications: First Line to Last ResortJun 2025
  2. Framing changes the response: 'I'm having an adrenaline release' lands very differently from 'I'm having a panic attack'.

    “telling yourself I'm having a panic attack is very different than telling, and we'll get to that in a second, but I'm having an adrenaline release. Like how you frame these things is really going to change how you respond to them”
    13:25Understanding Anxiety, GAD, and Treatments of AnxietyJun 2025
  3. Propranolol treats the perception of physiological arousal as a threat. If you can learn to perceive that arousal as non-threatening, or even as excitement, you can modulate your body's response, though not overnight.

    “it's essentially treating the perception of physiological arousal as a threat. If you can perceive physiological arousal as non-threatening, relatively speaking, or even as excitement instead, you will be able to modulate your body response. It's not something you can do overnight”
    34:59Psychiatrist's Guide to Anxiety Medications: First Line to Last ResortJun 2025
  4. Warn anxious patients that some side effects are as bad as they will get at the start, level out in about three days, and usually feel a little normal by about a week.

    “The side effects are going to be certain side effects are going to be as bad as they're going to be when you first start the medication. And it takes about three days for it to kind of level out. And usually about one week until you start to feel a little bit normal”
    20:38Psychiatrist's Guide to Anxiety Medications: First Line to Last ResortJun 2025

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From these episodes

Every point above is something said on the Psychofarm podcast, with the words as spoken and a link to the moment in the episode. It is education, not medical advice, and an episode reflects what we thought when we recorded it.

Educational content only. Everything here is what was said on the Psychofarm podcast, for clinicians. It is not medical advice and not a substitute for clinical judgment, current labeling or guidelines. An episode reflects what we thought when we recorded it, so check anything before you rely on it.