What We’ve Said

What we’ve said about Diagnostic hierarchy

23 points from 3 episodes, newest first

Also searched as hierarchy of diagnoses

In short

The diagnostic hierarchy does not mean assuming the top diagnosis is there; it means that when you have evidence for two, you treat the higher one first, so you do not call secondary symptoms ADHD or a personality disorder. Rather than giving every DSM diagnosis a patient meets, step back, look for the best explanation, and rank diagnoses by how well validated they are, from organic disease through schizophrenia and manic-depressive illness down to narrow syndromes like ADHD. A competing view weighs each diagnosis on its own evidence and applies a hierarchy only when mania, psychosis or OCD would hide other features.

What it is

  1. It does not mean you assume the condition at the top of the hierarchy is present. It means that if you have evidence for both, you must treat the one higher up before the lower one.

    “I want to emphasize it doesn't mean that you assume the one at the top of the hierarchy is there. It's that if you have evidence for both, you must treat the one on top of the hierarchy before the lower one, if you have evidence for both”
    18:24ADHD Is Not the Only Diagnosis: Differential and Diagnostic HierarchyNov 2025
  2. Even simplified and imperfect, the hierarchy keeps you from diagnosing conditions that are secondary to another one: ADHD before treating mood symptoms that impair concentration, or a personality disorder before treating mood symptoms that may be exaggerating personality traits.

    “the hierarchy, even if it's simplified and not perfect, makes sure that you don't diagnose conditions that are secondary to another condition, that you're not diagnosing ADHD before treating mood symptoms, which are leading to difficulty with concentrating. You're not diagnosing a personality disorder before treating mood symptoms that could be exacerbating personality aspects”
    56:27Understanding Borderline Personality Disorder with Dr. Mark L. RuffaloDec 2024
  3. One proposal rates each diagnosis on its empirical validity: the more robustly validated disorders get priority, and you move down the hierarchy only if the patient does not meet criteria for them. It puts validity ahead of reliability, because reliability is important but comes when you are studying real things.

    “we ought to rate each diagnosis on its empirical validity. How valid is And we develop a sort of hierarchy where the more robustly validated disorders are prioritized in diagnosis, and you sort of move down the hierarchy if the patient doesn't meet the criteria for the more Robustly Validated Disorders”
    16:59Diagnostic Hierarchy Explained: Why Patients Get 5 DiagnosesNov 2026Guest episode
    Also said in 1 more episode
    “we need to go back and we need to restore a focus on validity and prioritize validity over reliability. Reliability is important, but you get reliability when you're studying real things”
    9:58Diagnostic Hierarchy Explained: Why Patients Get 5 DiagnosesNov 2026Guest episode
  4. DSM-III, and especially DSM-III-R, removed a lot of the hierarchy. That made it possible to diagnose generalized anxiety disorder and major depressive disorder, or autism and ADHD, in the same patient.

    “Starting with DSM-3 and especially DSM-3R, which I think is published in 1988, it removes actually a lot of the hierarchy from DSM. So it becomes possible, for instance, to diagnose generalized anxiety disorder and major depressive disorder in the same patient. Now we can diagnose autism and ADHD in the same patient”
    19:36Diagnostic Hierarchy Explained: Why Patients Get 5 DiagnosesNov 2026Guest episode
  5. Think of a cough: a patient who tells their primary care doctor they have one is not told they have a cough disorder. We have to figure out what is going on underneath.

    “Patient comes into primary care doctor. And they go, I have a cough. They don't get told they have a cough disorder. We have to figure out what's going on underneath”
    21:52Diagnostic Hierarchy Explained: Why Patients Get 5 DiagnosesNov 2026

How we use it

  1. When a patient has symptoms from several chapters of the DSM, the most immediate step is to step back and think harder about what might be driving all of them. Psychiatrists used to apply Occam's razor and look for the single best explanation; that does not mean comorbidity does not exist, or that it is necessarily just one illness.

    “the most immediate recommendation is to try to take a step back, think a little bit harder about what might be driving all of these symptoms. That doesn't necessarily mean it's just one illness”
    49:51Diagnostic Hierarchy Explained: Why Patients Get 5 DiagnosesNov 2026Guest episode
    Also said in 1 more episode
    “Psychiatrists looked to use the principles of Occam's razor, the rule of parsimony. What is the best sort of Explanation for this patient's psychiatric illness. And it didn't mean that comorbidity didn't exist or doesn't exist, but in general, we should sort of look for the single best explanation”
    19:09Diagnostic Hierarchy Explained: Why Patients Get 5 DiagnosesNov 2026Guest episode
  2. At the top are organic disorders: medical and biological conditions such as brain problems, thyroid problems and cortisol, depending on the disorder in question.

    “i think the top is organic disorders um so we're talking about any sort of medical conditions biological conditions um depending on the disorder you're going to be looking for i think brain problems thyroid problems cortisol all that good stuff”
    18:57ADHD Is Not the Only Diagnosis: Differential and Diagnostic HierarchyNov 2025
  3. True OCD sits between the schizophrenia and bipolar level and the depression level. Sometimes it is severe and biological enough to be on the same level as psychosis and bipolar disorder.

    “True OCD, I would file that between the schizophrenia bipolar level and the level that you had below that, which was what? Depression? Depression, yeah. And sometimes OCD is severe and biological enough to really be on the same level as the psychosis and bipolar section”
    19:49ADHD Is Not the Only Diagnosis: Differential and Diagnostic HierarchyNov 2025
  4. Many child psychiatrists rightly put ADHD higher in their hierarchy, because before about age 17 the other conditions are far rarer.

    “many child psychiatrists rightfully put adhd much higher in their diagnostic hierarchy because the fact is before the age of 17 all the other conditions that we just mentioned are way more rare okay”
    22:12ADHD Is Not the Only Diagnosis: Differential and Diagnostic HierarchyNov 2025
  5. Ranked by validity, the organic diseases such as Alzheimer's disease come first. Beyond them come schizophrenia, manic-depressive illness (not necessarily the same as bipolar disorder), severe recurrent unipolar depression (melancholia), chronic low-grade depression that seems part of the patient's personality, OCD, classic autism (a bit different from autism spectrum disorder) and addiction. There is some question whether PTSD is as valid as something like schizophrenia.

    “what's most valid? Well, certainly the organic diseases like Alzheimer's disease. But beyond the organic conditions in psychiatry, I think we have to begin with schizophrenia. With manic depressive illness, which is not necessarily equivalent to bipolar disorder”
    39:53Diagnostic Hierarchy Explained: Why Patients Get 5 DiagnosesNov 2026Guest episode
    Also said in 2 more episodes
    “I would add severe recurrent unipolar depression, what Max Fink and Edward Shorter have called melancholia, which is a similar construct. Depressive neurosis or neurotic depression, chronic depression, Low-grade depression that seems to be a part of the patient's personality”
    40:19Diagnostic Hierarchy Explained: Why Patients Get 5 DiagnosesNov 2026Guest episode
    “I think there's some question about validity of post-traumatic stress disorder, whether it's as valid as something like schizophrenia. I forgot obsessive compulsive disorder. That's highly valid. Classic autism. Which is a bit different than Autism Spectrum Disorder. Addiction”
    42:01Diagnostic Hierarchy Explained: Why Patients Get 5 DiagnosesNov 2026Guest episode
  6. Among the personality disorders, borderline and antisocial are the two that are pretty robustly validated, though personality disorders may belong on the second level rather than the top.

    “Within the personality disorders category, I think there are two personality disorders that are pretty robustly validated, and that's borderline personality disorder and antisocial personality disorder”
    41:02Diagnostic Hierarchy Explained: Why Patients Get 5 DiagnosesNov 2026Guest episode
    Also said in 1 more episode
    “I think Ron and I may have some disagreements here. I'm not speaking for Ron, but I think that maybe the personality disorders might be on level two”
    41:50Diagnostic Hierarchy Explained: Why Patients Get 5 DiagnosesNov 2026Guest episode
  7. There may also be a hierarchy within each major modality of psychopathology (mood, personality, thought disorder and so on). Within the schizophrenia spectrum, schizophrenia would sit at the top, with conditions such as delusional disorder lower because they may not be as robustly validated.

    “a tool that we call the PRISM psychopathology refracted into seven modalities, that there's sort of like seven major modalities of psychopathology. Psychopathology, mood, personality, thought disorder, et cetera. And that maybe within each of those major modalities, there would be a hierarchy as well”
    43:44Diagnostic Hierarchy Explained: Why Patients Get 5 DiagnosesNov 2026Guest episode
    Also said in 1 more episode
    “within thought disorders or schizophrenia spectrum, schizophrenia would be at the top. And then lower than that would be things like delusional disorder, et cetera, that may not be as robustly validated”
    44:08Diagnostic Hierarchy Explained: Why Patients Get 5 DiagnosesNov 2026Guest episode
  8. ADHD falls very low: it is a very narrow syndrome, and it is hard to think of a major psychiatric syndrome that does not involve problems with concentration and attention. Basically, you have to rule everything else out.

    “can either of you think of a major psychiatric syndrome that doesn't involve problems with concentration and attention? So for me, ADHD is really falls very low. It's a very narrow syndrome that falls very low on the hierarchy. Basically, you have to rule everything else out”
    23:21Diagnostic Hierarchy Explained: Why Patients Get 5 DiagnosesNov 2026Guest episode
  9. Use the hierarchy together with a differential diagnosis. The job is not to know for certain what the diagnosis is, but to have a prediction, a percentage for how well it fits, and an order.

    “the ability to think in terms of a hierarchy and then also think in terms of a differential diagnosis where I don't think of my job as knowing for certain what the diagnosis is. But knowing, having a prediction and a percentage that I think it fits and then an order”
    21:28Diagnostic Hierarchy Explained: Why Patients Get 5 DiagnosesNov 2026

A different view

  1. Another view is that there is no hierarchy: you weigh each possible diagnosis and find which ones are supported. A hierarchy applies only when there are clearly enough symptoms of mania, hypomania, acute psychosis or OCD to impair your ability to elicit or observe the features of another condition.

    “I believe that you have to weigh each possible diagnosis and find which ones are supported. There's no hierarchy. There's a hierarchy if there's obviously sufficient symptoms of certain conditions, right? Mania, hypomania, acute psychosis, OCD, that would impair your ability to elicit or observe the diagnostic features of another condition”
    55:55Understanding Borderline Personality Disorder with Dr. Mark L. RuffaloDec 2024
  2. Do not hold back a borderline diagnosis when the evidence is there. Nobody says they do not like to jump to bipolar disorder, schizophrenia or major depression; you go off the clinical evidence.

    “Would you ever say, I don't like to jump to bipolar disorder? I don't like to jump to schizophrenia. I don't like to jump to major depression. No one says that. You go off the clinical evidence”
    54:14Understanding Borderline Personality Disorder with Dr. Mark L. RuffaloDec 2024

Pitfalls and myths

  1. Do not give every DSM diagnosis a patient meets criteria for. The idea is tempting, but it is a very harmful way of thinking, philosophically and scientifically flawed.

    “I think we're just tempted to believe this idea that If there is a diagnosis in the DSM and the patient meets the criteria for the diagnosis, we give the diagnosis. I think it's actually a very harmful way of thinking that's really philosophically and scientifically flawed”
    51:08Diagnostic Hierarchy Explained: Why Patients Get 5 DiagnosesNov 2026Guest episode
  2. Psychiatry has a rampant comorbidity problem, and a validity-based hierarchy would help resolve a lot of what is really spurious or false comorbidity.

    “We have a rampant comorbidity problem, and that's the other issue that we talk about in the paper. And this sort of idea would help resolve a lot of what we believe is really spurious or false comorbidity in psychiatry”
    10:27Diagnostic Hierarchy Explained: Why Patients Get 5 DiagnosesNov 2026Guest episode
  3. Without the hierarchy, a trainee presents a patient with bipolar disorder, MDD, ADHD and GAD who now cannot focus, with no frame of reference for how to think through the problem or which medication to start. Patients end up on higher and higher doses of stimulants, or running through antidepressant after antidepressant.

    “they go, you know, I have a patient, they have bipolar. MDD, ADHD, GAD, Lupus. Yeah. And now they can't focus and I don't know what medication I should go start. They don't really have a frame of reference for how to even think through the problem”
    21:04Diagnostic Hierarchy Explained: Why Patients Get 5 DiagnosesNov 2026
    Also said in 1 more episode
    “how often do we see patients on higher and higher doses of stimulants? Patients who, you know, they're running through the gambit of different antidepressants because the persons were not thinking through the hierarchy appropriately”
    22:02Diagnostic Hierarchy Explained: Why Patients Get 5 DiagnosesNov 2026
  4. The hierarchy is badly undertaught: every time we ask psychiatry residents, even at reputable residencies, at least 80 percent have never heard of it.

    “Do you guys know what the diagnostic hierarchy is? And every single time, at least 80% have never heard of it. And this is residents. This is psychiatry residents at reputable residencies”
    1:27Diagnostic Hierarchy Explained: Why Patients Get 5 DiagnosesNov 2026

Pearls

  1. The hierarchy matters in therapy too: if something fundamentally more medical or biological is going on that will not respond to talk therapy alone, ignoring it means not much progress.

    “If there's something fundamentally more medical, biological that will not respond to a talk therapy alone, ignoring that you're not going to get much progress”
    36:21Diagnostic Hierarchy Explained: Why Patients Get 5 DiagnosesNov 2026
  2. Keep it usable. The more complex a hierarchy is, the more accurate it probably is, but the less people will follow it, and one the average clinician cannot understand will not get used.

    “the challenge of the more complex it is, probably the more accurate it is, but also the less adherent people will be. And it's so complex that the average clinician can't even understand it. It's not going to get used”
    44:23Diagnostic Hierarchy Explained: Why Patients Get 5 DiagnosesNov 2026
  3. Aim for a broad knowledge of psychopathology across all of humanity, so you stay aware of how your own practice, which sees only one slice of it, biases you.

    “I would prefer for every clinician to have such a broad knowledge Of all humanity in psychopathology, that we would be individually aware of how biased our own practices, that we are seeing specifically this slice of humanity rather than the other”
    46:02Diagnostic Hierarchy Explained: Why Patients Get 5 DiagnosesNov 2026

From these episodes

Every point above is something said on the Psychofarm podcast, with the words as spoken and a link to the moment in the episode. It is education, not medical advice, and an episode reflects what we thought when we recorded it.

Educational content only. Everything here is what was said on the Psychofarm podcast, for clinicians. It is not medical advice and not a substitute for clinical judgment, current labeling or guidelines. An episode reflects what we thought when we recorded it, so check anything before you rely on it.