Build the differential from the major DSM chapters first, include personality, and check substances and medical causes in every patient. Do not go straight to the diagnosis the patient or everyone else brings (ADHD, meth, major depression); rule the alternatives in or out and keep re-evaluating.
How we build it
While gathering the narrative, use the major DSM chapters as your differential. Do not drill down to a specific diagnosis within each chapter yet; think of the major category first.
“using the major DSM chapters, being aware of their names, use that as your major differential diagnosis. Don't drill down to a specific diagnosis within each chapter just yet. Simply think of the major category first”
31:09How to Do a Psychiatric Intake | The Art and Science of the First HourSep 2025 Run through the categories: psychosis, bipolar, depression, anxiety, OCD, trauma, dissociative disorders, somatic disorders, eating disorders, sleep problems, sexual problems, impulse control and addiction.
“It's like psychosis, bipolar, depression, anxiety, OCD, trauma, dissociative disorders, somatic disorders, eating disorders, sleep problems, sexual problems, impulse control, addiction”
31:29How to Do a Psychiatric Intake | The Art and Science of the First HourSep 2025 Personality is the most clinically neglected category today, and it is the one thing every single patient who walks through your door is going to have.
“personality is the one thing that every single patient that walks through your door is going to have, as opposed to all the other diagnostic and pathological categories”
21:31Is Psychoanalysis Still Relevant in Modern Psychiatry?Oct 2025 Also said in 1 more episode
“and personality is the most neglected one i'm gonna say personality is the most clinically neglected category today uh but we'll leave that side um”
31:52How to Do a Psychiatric Intake | The Art and Science of the First HourSep 2025 Consider all the possibilities, not just medical diagnoses like autism or neurodiversity. Rational behaviors belong on the list too.
“just like in a forensic psychiatry analysis of a moment of any person's behavior, we need to consider all the different possibilities, not just the possibilities that are medical diagnoses like autism or neurodiversity, right? We want to consider rational behaviors”
31:09The Psychology of Elizabeth Holmes in You Can See Everything: Narcissism, Autism, or Manipulation?Oct 2026 Connect your conclusion to what you are actually seeing, and the best way to do that is to consider the context.
“you need to make connection between your conclusion and what you're seeing. And again, the best way to do that is to actually consider the context”
18:50Lindsay Clancy Trial: A Forensic Psychiatrist Explains Psychosis, Malingering, & the Insanity DefenseSep 2026 Think in terms of a differential and of the diagnostic hierarchy together. The job is not to know for certain what the diagnosis is, but to have a prediction, a percentage for how well it fits, and an order.
“the ability to think in terms of a hierarchy and then also think in terms of a differential diagnosis where I don't think of my job as knowing for certain what the diagnosis is. But knowing, having a prediction and a percentage that I think it fits and then an order”
21:28Diagnostic Hierarchy Explained: Why Patients Get 5 DiagnosesNov 2026
Substances and medical causes
In every patient, consider substances, herbs, supplements, natural remedies, energy drinks, caffeine, medical conditions and other psychiatric conditions, eating disorders included: if you are not eating correctly, you will not function correctly.
“please consider what kind of substances, herbs, supplements, natural remedies, energy drinks, caffeine, medical conditions, other psychiatric conditions. Like I mentioned, the eating disorders, if you're not eating correctly, you're not going to be able to function correctly”
46:07ADHD Is Not the Only Diagnosis: Differential and Diagnostic HierarchyNov 2025 For anxiety, assess fully for other physiological and medical causes, especially substances, before medication management.
“When we talk about medication management, assess entirely for other physiological and medical causes, especially substances of anxiety”
1:00:24Psychiatrist's Guide to Anxiety Medications: First Line to Last ResortJun 2025 For a bipolar picture, consider medication- and substance-induced bipolar-type disorders, and medically induced ones from strokes, head injuries and seizure disorders.
“you really need to consider the possibility of both medication and substance-induced bipolar-type disorders. You should also consider medically-induced bipolar-type disorders, for example, from strokes, head injuries, and seizure disorders”
48:44How to Diagnose Bipolar Disorder: The Interview Framework That Beats Screening QuestionsFeb 2026 Just because everyone (the patient, the parents, you yourself) has said it's meth does not mean you should automatically assume that's that.
“just because everyone has told you that it's meth, the patient has told you, you have told yourself that it's meth, and the parents have told you that it's meth, doesn't mean that you should automatically assume that's that”
26:16Involuntary Treatment & Agency, Thoughts and Feelings | Episode 19Mar 2025
Common mimics
Do not go straight for ADHD. Rule in and rule out the other comorbidities you have evidence for.
“you can't take the approach of going straight for the ADHD. Instead, you have to essentially rule in and rule out the other comorbidities that you have evidence for”
23:55How to Decide When ADHD Is Actually ADHDNov 2025 The biggest alternative to ADHD we see is depression or adjustment disorder, mood symptoms that make it hard to concentrate, followed by anxiety that drives a lot of avoidance of tasks.
“the biggest one I see is depression slash adjustment disorder. Mood symptoms that are making it difficult to concentrate. I'll throw anxiety in there and that people are really anxious and that makes it so that they're using a lot of avoidance for tasks”
14:29ADHD Is Not the Only Diagnosis: Differential and Diagnostic HierarchyNov 2025 The most common explainers are depressive, anxiety and trauma disorders. OCD is on the list not because it is frequent but because it is important.
“my prepared list in terms of my own experiences about what is probably the most common explainers is depressive disorders, anxiety disorders, trauma disorders. That's a big one. I put OCD here not because it's frequent, but I think it's important”
16:11ADHD Is Not the Only Diagnosis: Differential and Diagnostic HierarchyNov 2025 What gets ignored most when the focus is symptomatic treatment: proper trauma disorders (not just a history of trauma) and mood disorders, and the most harmful one to miss is bipolar disorder.
“the biggest things that are ignored are trauma disorders, proper trauma disorders, not just people of history, trauma, um, What else is ignored is mood disorders, and the most harmful one to ignore is, of course, bipolar disorder”
12:05You Tell Me | Adderall for All?, Surgeons Gone Shrink, Codependency isn't NeurobiologicalJul 2025 Borderline conditions are the great mimicker of psychiatry. They can look like so many other named conditions, which makes them hard to understand accurately.
“Borderline conditions, I think, are the great mimicker of psychiatry, right? It can look like so many other known and named conditions. It makes it particularly difficult to accurately understand”
41:12Treating Borderline Personality Effectively aka How To Be A Good Psychiatrist Through GPMMay 2025 PTSD requires a temporal relationship and sequence between the trauma and the syndrome, because its symptoms and impairments are common in other conditions as well.
“You need to find a temporal relationship and a sequence between this syndrome and those traumas. Why? Because as you can expect, after having gone through all of these criteria, these are all symptoms and impairments that are commonly seen in other conditions as well”
43:20Trauma and PTSD: How the DSM Criteria Actually Help Us Understand What’s Going OnOct 2026 Also said in 1 more episode
“You need to find a temporal relationship and a sequence between this syndrome and those traumas. Why? Because, as you can expect, after having gone through all of these criteria, these are all symptoms and impairments that are commonly seen in other conditions as well”
41:29Understanding Trauma and PTSD, Diagnosis and Dissociation | Episode 21Apr 2025 Social communication problems do not mean autism. As with almost every DSM disorder, multiple things can explain the same deficits.
“It's important to note that having these issues does not mean that you have autism. This is only one arm of the ASD definition and there's a lot more to it. And like almost every other disorder in the DSM, there are multiple possible things that can explain the same deficits, right? The differential diagnosis process is key in diagnosis”
6:25Autism Diagnosis Explained: DSM-5 Criteria, Autistic Traits & the Difficult DifferentialSep 2026 The autism criteria are not aggressive enough about "not better explained by", probably because the people who framed the diagnosis mostly work with children.
“I don't think they are aggressive enough about the not better acceptable aspect. Yeah, the differential diagnosis. And I think it's probably because autism researchers and the framers of the definition of this diagnosis probably mostly work with children”
14:09Autism Diagnosis Explained: DSM-5 Criteria, Autistic Traits & the Difficult DifferentialSep 2026 When symptoms pile up, ask what single condition might be driving them. A personality disorder might be causing depression in the face of rejection or abandonment, anxiety in interpersonal situations and poor sleep because relationships are up and down. With a father, grandfather and uncle with bipolar illness, it may be a subsyndromal bipolar condition: always cycling, anxious, and sometimes unable to sleep because the mind is racing.
“Does this patient have a personality disorder that might be causing them to become depressed in the face of rejection or abandonment? They might be anxious in interpersonal situations. They might be having trouble sleeping because their relationships are up and down”
50:22Diagnostic Hierarchy Explained: Why Patients Get 5 DiagnosesNov 2026Guest episode Also said in 1 more episode
“Do they have a father and grandfather and uncle with bipolar illness? And this patient has some subsyndromal bipolar condition where they're always cycling and they're also anxious and they can't sleep sometimes because their mind is racing”
50:45Diagnostic Hierarchy Explained: Why Patients Get 5 DiagnosesNov 2026Guest episode
Pitfalls
The biggest early-career mistake: this person feels depressed and talks about depression symptoms, so they have major depression. That is just not always the case.
“Patient comes into primary care doctor. And they go, I have a cough. They don't get told they have a cough disorder. We have to figure out what's going on underneath”
21:52Diagnostic Hierarchy Explained: Why Patients Get 5 DiagnosesNov 2026 Also said in 1 more episode
“probably the biggest mistake that early career and trainee people in mental health treatment make is that they say, this person feels depressed. They're talking about depression symptoms. They have major depression, right? And that's just not always the case”
3:38Treating Depression: Practical Tips & Pearls for Anti-Depressant MedicationsJan 2025 After confirmed suicidal threats, the top of the differential is usually substances, personality and mood disorders. When dangerousness is high, you cannot responsibly assess on one look at a patient's statements and behaviors.
“So top of the differential usually is substances, personality, and mood disorders. OK, so now you're going to assess for those and you're going to you can't just assess responsibly when there is high dangerousness based on the output statements and behaviors on one look of a patient”
54:06Involuntary Treatment & Agency, Thoughts and Feelings | Episode 19Mar 2025 Clinicians say they do not like to "jump to" a personality diagnosis. Imagine saying that about bipolar disorder, an eating disorder or an anxiety disorder.
“Imagine if you said that about any other diagnosable psychiatric condition. Oh, I don't like to jump to bipolar. Oh, I don't like to jump to an eating disorder. I don't like to jump to an anxiety disorder”
17:17What Psychiatrists Get Wrong About Personality DisordersOct 2024
Talking to patients
No doctor can talk to you for 45 minutes and know with 100% confidence what your diagnoses are, and you cannot rule conditions out that way either.
“A doctor can't talk to you for 45 minutes and know with 100% confidence what your diagnoses are. And you essentially can't rule out conditions by meeting and talking to someone with 45 minutes”
45:07Lindsay Clancy Trial: A Forensic Psychiatrist Explains Psychosis, Malingering, & the Insanity DefenseSep 2026 Never say never. Not "you absolutely don't have this" but "my working theory is this, and we will keep screening, monitoring and watching."
“a good clinician, their motto should be never say never, right? It's not, you absolutely don't have this. It's that my working theory is currently this, but we're going to continue to screen, monitor, and watch out for XYZ”
46:27Lindsay Clancy Trial: A Forensic Psychiatrist Explains Psychosis, Malingering, & the Insanity DefenseSep 2026
It also comes up on
- Psychiatric intakeRead through all of the DSM-5. Each diagnosis has a differential diagnosis section under its criteria that strengthens your core knowledge.
- DelusionsAn overvalued idea. A rigid theory about one's own illness puts overvalued idea at the top of the differential: people get all kinds of wild theories about their illnesses.
- Diagnostic uncertaintyYou do not have to commit to a diagnosis at the first meeting. Tell the patient what is on your differential and why, and that time is the only thing that will tell you the actual diagnosis.
- Overvalued ideasWhen a patient holds a rigid theory about their own illness, overvalued idea goes at the top of the differential. People develop all kinds of wild theories about their illnesses.
- Personality disordersThe DSM itself says that in adolescents and adults ADHD may be hard to distinguish from borderline, narcissistic and other personality disorders. Older editions named it explicitly as an explainer, and the DSM-5-TR still lists it in the differential.
- Psychiatric diagnosisDo not feel pressure to make a diagnosis at the end of a first appointment. Say what is on your differential and why, and that time is the only thing that will tell.
- Psychiatric intakeDo not feel pressure to make a diagnosis at the end of a first appointment. Tell the patient what is on your differential; with experience, uncertainty goes up, and one 45-minute conversation cannot name all of someone's problems.
- Psychiatric trainingIf you have not read through all of DSM-5, do. Each diagnosis has a differential diagnosis section under the criteria that strengthens your core knowledge.
From these episodes
- Diagnostic Hierarchy Explained: Why Patients Get 5 DiagnosesNov 2026 · 4 points
- The Psychology of Elizabeth Holmes in You Can See Everything: Narcissism, Autism, or Manipulation?Oct 2026 · 1 point
- Trauma and PTSD: How the DSM Criteria Actually Help Us Understand What’s Going OnOct 2026 · 1 point
- Autism Diagnosis Explained: DSM-5 Criteria, Autistic Traits & the Difficult DifferentialSep 2026 · 2 points
- Lindsay Clancy Trial: A Forensic Psychiatrist Explains Psychosis, Malingering, & the Insanity DefenseSep 2026 · 3 points
- How to Diagnose Bipolar Disorder: The Interview Framework That Beats Screening QuestionsFeb 2026 · 1 point
- How to Decide When ADHD Is Actually ADHDNov 2025 · 1 point
- ADHD Is Not the Only Diagnosis: Differential and Diagnostic HierarchyNov 2025 · 3 points
- Is Psychoanalysis Still Relevant in Modern Psychiatry?Oct 2025 · 1 point
- How to Do a Psychiatric Intake | The Art and Science of the First HourSep 2025 · 3 points
- You Tell Me | Adderall for All?, Surgeons Gone Shrink, Codependency isn't NeurobiologicalJul 2025 · 1 point
- Psychiatrist's Guide to Anxiety Medications: First Line to Last ResortJun 2025 · 1 point
- Treating Borderline Personality Effectively aka How To Be A Good Psychiatrist Through GPMMay 2025 · 1 point
- Understanding Trauma and PTSD, Diagnosis and Dissociation | Episode 21Apr 2025 · 1 point
- Involuntary Treatment & Agency, Thoughts and Feelings | Episode 19Mar 2025 · 2 points
- Treating Depression: Practical Tips & Pearls for Anti-Depressant MedicationsJan 2025 · 1 point
- What Psychiatrists Get Wrong About Personality DisordersOct 2024 · 1 point
Every point above is something said on the Psychofarm podcast, with the words as spoken and a link to the moment in the episode. It is education, not medical advice, and an episode reflects what we thought when we recorded it.