Trauma is over-referenced but PTSD is under-identified: most people with a criterion A trauma never develop it, yet many true PTSD patients carry a depression label through trial after trial. Diagnose it by walking the actual criteria and the timeline, watch for its mimics (depression, mania, ADHD, psychosis), and treat it with trauma-focused psychotherapy first, using medication mainly to stabilize sleep and safety so the patient can do that work.
What it is
Sticking to the DSM model of PTSD has real clinical and legal value: it ties you to a well-researched, well-constructed and unique syndrome. Not everyone who goes through trauma gets PTSD as the DSM defines it.
“there is a utility and there's a legal Clinical Reality to Preserving and Utilizing the DSM Model for Post Traumatic Stress Disorder. Being very specific with that criteria is useful because it sort of ties you to a well-researched and fairly well-constructed syndrome”
2:11Trauma and PTSD: How the DSM Criteria Actually Help Us Understand What’s Going OnOct 2026 Also said in 1 more episode
“and there's a legal clinical reality to preserving and utilizing the dsm model for post-traumatic stress disorder Being very specific with that criteria is useful because it sort of ties you to a well-researched and fairly well-constructed syndrome that is unique. And not everyone that undergoes traumas gets PTSD as defined in the DSM”
2:05Understanding Trauma and PTSD, Diagnosis and Dissociation | Episode 21Apr 2025 Not everyone who has even a big-T trauma develops PTSD, and not everyone who develops it keeps it. By some research, the majority remit without any treatment within a year.
“not everyone who experiences a traumatic event, even of the big T variety, will go on to develop PTSD. And not everyone who develops PTSD will continue to have it. In fact, based on some research, you could say that the majority of people will go into remission without any treatment within a year”
11:29Trauma and PTSD: How the DSM Criteria Actually Help Us Understand What’s Going OnOct 2026 Also said in 1 more episode
“not everyone who experiences a traumatic event, even of the big T variety, will go on to develop PTSD. And not everyone who develops PTSD will continue to have it. In fact, based on some research, you could say that the majority of people will go into remission without any treatment within a year”
11:21Understanding Trauma and PTSD, Diagnosis and Dissociation | Episode 21Apr 2025 One picture of it: fight or flight goes off, the person is trapped and cannot escape, and the event overwhelms their ideas of how the world works and of self and others.
“I think of it as an event where someone's fight or flight goes off and for whatever reason they... get trapped and they can't escape from the situation. And it's usually an event that is so overwhelming to like a person's ideas of how the world works or their ideas of self or others”
12:09Understanding Trauma and PTSD, Diagnosis and Dissociation | Episode 21Apr 2025 It does not take that severity. A complicated death in the family, finding someone dead at home, or simply a car accident can be enough in vulnerable people.
“you don't need trauma to that severity to develop a PTSD, even the severe one, you know, it can be as simple as seeing, you know, a very complicated death of family members, you know, finding someone dead in your home. It can be simply a car accident in some vulnerable individuals”
14:39Trauma and PTSD: How the DSM Criteria Actually Help Us Understand What’s Going OnOct 2026 Much persistent adult-onset PTSD is like panic disorder. Panic disorder is not having panic attacks but fearing and avoiding them, and PTSD that persists, with or without treatment, is often an avoidance of trauma memories.
“Panic disorder isn't having the panic attacks. It's having fear and avoidance of the panic attacks. I find that in many cases of persistent PTSD that persists with treatment or without treatment, it's that there's an avoidance of trauma memories”
15:17Trauma and PTSD: How the DSM Criteria Actually Help Us Understand What’s Going OnOct 2026 Also said in 1 more episode
“I would say in many, many cases that you see, especially for adult onset PTSD, the issue is more akin to a panic disorder issue, right? Think of a panic disorder. The panic disorder isn't having the panic attacks”
14:57Understanding Trauma and PTSD, Diagnosis and Dissociation | Episode 21Apr 2025 The crux of its psychology is cognitive and behavioral avoidance strategies to avoid distressing emotional reactions.
“the crux of the psychology of PTSD is that a patient develops cognitive and behavioral avoidance strategies to avoid distressing emotional reactions”
23:23PTSD Medications: Integrating Pharmacotherapy, Therapy, and the Treatment Frame | Episode 22Apr 2025 In predictive terms, the brain's prediction network expects threat and danger far too much, like someone jolted by fireworks.
“You could think of PTSD as one where the prediction network of the brain just expects threat. endanger so much that's out of whack, just like someone hearing the fireworks, for example”
24:12PTSD Medications: Integrating Pharmacotherapy, Therapy, and the Treatment Frame | Episode 22Apr 2025 The stress response is always on and gets provoked by the littlest things. When the amygdala lights up, Broca's speech area goes offline, so there is no verbal, cognitive processing during flashbacks.
“when this amygdala is lit off, when you look at the brain, the Broca's area, which is the speech area, goes offline. So there isn't verbal acknowledgement and a cognitive process that's occurring when you're getting these flashbacks”
32:07Trauma and PTSD: How the DSM Criteria Actually Help Us Understand What’s Going OnOct 2026 Also said in 1 more episode
“your body kind of always has its stress response on. Like that hypervigilance, that lit up amygdala is just all the time and it gets provoked at the littlest things. So someone who doesn't have PTSD, you need to see maybe some violence picking up, something scary to have that stress response picked up”
30:38Understanding Trauma and PTSD, Diagnosis and Dissociation | Episode 21Apr 2025 A normal memory integrates sensations, emotions and thoughts into your sense of self and other. In trauma those parts do not get integrated into a whole experience that can be processed.
“in a normal memory, you have this integration of the sensations, the emotions, the thoughts that you were having. And it gets integrated into your idea of self and other. When you have a traumatic event, it's almost as if all these different parts don't get integrated”
32:46Trauma and PTSD: How the DSM Criteria Actually Help Us Understand What’s Going OnOct 2026 Also said in 1 more episode
“in a normal memory, you have this integration of the sensations, the emotions, the thoughts that you were having, and it gets integrated into your idea of self and other. When you have a traumatic event, it's almost as if all these different parts don't get integrated into a holistic experience of an event that's able to be processed”
31:48Understanding Trauma and PTSD, Diagnosis and Dissociation | Episode 21Apr 2025 Shame is a major, often unacknowledged part of trauma: shame about the event, and shame about not enjoying positive things, so patients feel like monsters.
“I think there's a lot of unacknowledged shame about the event, about the trauma. I think patients also get a deep sense of shame for... Because a lot of times with that negative cognition means that they're not enjoying positive events and they feel ashamed and feel like monsters”
26:56Trauma and PTSD: How the DSM Criteria Actually Help Us Understand What’s Going OnOct 2026 Also said in 1 more episode
“Now, another thing I wanted to talk about in regards to this area is shame and how shame is just a major aspect of what patients with trauma experience. I think there's a lot of unacknowledged shame about the event, about the trauma”
25:47Understanding Trauma and PTSD, Diagnosis and Dissociation | Episode 21Apr 2025 Calling the deeper changes merely psychological undersells them. For religious or spiritual people it can feel almost like a loss of faith.
“I just don't think that it captures enough how deep the feelings and problems are if we simply call it psychological problems. I don't think it's so simple. If you talk to people who are religious and spiritual, it can be felt almost as some kind of a loss of faith or a whole”
45:15Understanding Trauma and PTSD, Diagnosis and Dissociation | Episode 21Apr 2025 In a ranking of diagnoses by validity, there is some question whether PTSD is as valid as something like schizophrenia.
“I think there's some question about validity of post-traumatic stress disorder, whether it's as valid as something like schizophrenia. I forgot obsessive compulsive disorder. That's highly valid. Classic autism. Which is a bit different than Autism Spectrum Disorder. Addiction”
42:01Diagnostic Hierarchy Explained: Why Patients Get 5 DiagnosesNov 2026Guest episode
How we diagnose it
Many clinicians diagnose PTSD without going through the criteria: they see a persistent fear or mood problem plus a criterion A trauma and call it PTSD. Walk the criteria.
“a lot of people out there in the community have a habit of diagnosing post-traumatic stress disorder without Actually going through the criteria. They can identify that someone is in a persistent fear or mood problem and that they have a criteria in a trauma and they say, well, they've got that”
15:57Trauma and PTSD: How the DSM Criteria Actually Help Us Understand What’s Going OnOct 2026 Also said in 1 more episode
“a lot of people out there in the community have a habit of diagnosing post-traumatic stress disorder without actually going through the criteria. They kind of identify that someone is in a persistent fear or mood problem And that they have a criteria in a trauma and they say, well, they've got that”
15:49Understanding Trauma and PTSD, Diagnosis and Dissociation | Episode 21Apr 2025 The criteria build on each other: a trauma (A), it comes back as re-experiencing (B), the person avoids it (C), and so on.
“Criterion A being that the person had a trauma. Then the trauma comes back to that person, so they have re-experiencing. Then the person avoids that trauma, so they have avoidance”
16:46CPTSD vs BPD: How to Think About the Difference and What to Do About ItMar 2026 Criterion A, big-T trauma, means direct threat to life, serious injury or sexual assault.
“big T trauma. I think that most people, when they refer to that, they're talking about DSM criterion A trauma and trauma. At least in the fifth edition, what we're thinking about, what we're considering meets that is going to be direct threats to life, serious injury, or for sexual assault”
3:49Trauma and PTSD: How the DSM Criteria Actually Help Us Understand What’s Going OnOct 2026 For clinical purposes it helps to add that it happened in a manner that shocked or scared you, closer to DSM-IV, though not strictly in the criteria. You need something reasonably objective matched by a subjective experience.
“while we need something reasonably objective, there still needs to be that subjective experience to match that thing that's reasonably objective”
6:12Trauma and PTSD: How the DSM Criteria Actually Help Us Understand What’s Going OnOct 2026 Also said in 2 more episodes
“I like to add in a manner that shocked or scared you, and I know that's a little bit more like DSM-IV, but I think that that's helpful to make that distinction, even though I understand it's not strictly in the DSM criteria. This is for clinical purposes”
4:16Understanding Trauma and PTSD, Diagnosis and Dissociation | Episode 21Apr 2025 “So I do think that while we need something reasonably objective, there still needs to be that subjective experience to match that thing that's reasonably objective”
6:01Understanding Trauma and PTSD, Diagnosis and Dissociation | Episode 21Apr 2025 Exposure is broad. Encountering traumatic material electronically as part of your work counts, a carve-out for people who work child abuse cases, and so does hearing people assaulted or killed in another prison cell.
“if you encounter traumatic material in an electronic format through your work as part of your work, that counts. It's a little carve out for people who, for example, work with child abuse cases”
4:54Trauma and PTSD: How the DSM Criteria Actually Help Us Understand What’s Going OnOct 2026 Also said in 2 more episodes
“if you encounter traumatic material in an electronic format through your work as part of your work, that counts. It's a little carve out for people who, for example, work with child abuse cases”
4:45Understanding Trauma and PTSD, Diagnosis and Dissociation | Episode 21Apr 2025 “just a witness um learning of um a lot of people in prison will hear people being sexually assaulted or killed or severely injured in another cell still can cause”
9:16Understanding Trauma and PTSD, Diagnosis and Dissociation | Episode 21Apr 2025 Unusual routes exist. A delusion or hallucination is not objectively threatening, but most people who could not tell it from reality would be threatened. And in forensics, people can develop PTSD from being the assailant.
“there's one more weird one that you only see in forensics. People can develop PTSD from being essentially the assailant, the murderer. Interesting, isn't it”
7:43Trauma and PTSD: How the DSM Criteria Actually Help Us Understand What’s Going OnOct 2026 Also said in 1 more episode
“If you encounter it because of a delusion, right? A hallucination. It's technically not objectively threatening. But I would say that that's a situation where most people encountering that and unable to tell it apart from reality would be objectively threatened”
7:15Understanding Trauma and PTSD, Diagnosis and Dissociation | Episode 21Apr 2025 Criterion B is intrusion: recurrent involuntary distressing memories, trauma-related dreams, dissociative reactions or flashbacks, intense or prolonged distress, and marked physiological reactions to reminders.
“recurrent involuntary distressing trauma memories. So trauma memories, distressing trauma-related dreams, dissociative reactions slash flashbacks, intense or prolonged psychological distress, and marked physiological reactions to trauma reminders”
17:22Trauma and PTSD: How the DSM Criteria Actually Help Us Understand What’s Going OnOct 2026 Also said in 1 more episode
“recurrent involuntary distressing trauma memories. So, trauma memories, distressing trauma-related dreams, dissociative reactions slash flashbacks, intense or prolonged psychological distress, and marked physiological reactions to trauma reminders”
17:13Understanding Trauma and PTSD, Diagnosis and Dissociation | Episode 21Apr 2025 Criterion C is avoidance of internal reminders (memories, thoughts, feelings) and external reminders (people, places, activities).
“avoidance or efforts to avoid distressing internal trauma reminders, memories, thoughts, or feelings. And then the second part is avoidance or efforts to avoid distressing external trauma reminders, people, places, activities”
18:36Trauma and PTSD: How the DSM Criteria Actually Help Us Understand What’s Going OnOct 2026 Also said in 1 more episode
“So C is avoidance. And then the two that I mentioned are avoidance or efforts to avoid distressing internal trauma reminders, memories, thoughts, or feelings. And then the second part is avoidance or efforts to avoid distressing external trauma reminders, people, places, activities”
18:24Understanding Trauma and PTSD, Diagnosis and Dissociation | Episode 21Apr 2025 Criterion D is a large, persistent change in how the person feels and relates to themselves and others. It is almost characterological, but it happens in people with no prior personality problems, and in clear cases outside war veterans you see it almost without exception.
“There are large scale and persistent changes in how the person who has been traumatized in the PTSD syndrome feels and relates to themselves and others. It's almost characterological, but you can see this happening in people who have not had character problems”
19:16Trauma and PTSD: How the DSM Criteria Actually Help Us Understand What’s Going OnOct 2026 Also said in 2 more episodes
“if you have, this is from my clinical experience now, sufficient experience with people who are not war veterans with PTSD, then you're going to see that in the really clear cases, almost without exception you are going to see criterion d”
19:12CPTSD vs BPD: How to Think About the Difference and What to Do About ItMar 2026 “there are large scale and persistent changes in how the person who has been traumatized in the PTSD syndrome feels and relates to themselves and others. It's almost character illogical, but you can see this happening in people who have not had character problems, personality problems throughout their lives until they've encountered these traumas”
19:07Understanding Trauma and PTSD, Diagnosis and Dissociation | Episode 21Apr 2025 Self-blame is a hallmark. Abused children blame themselves and think it is because they are bad, often confused by any part that was exciting. Adults show an irrational self-blame they can see is irrational yet believe almost 100 percent, like the person who was at every appointment and still feels they could have done more for a dying parent.
“It's an irrational self-blame that they can be aware is irrational, yet they can believe almost 100%, even if they're cognitively aware that it's irrational”
22:40Trauma and PTSD: How the DSM Criteria Actually Help Us Understand What’s Going OnOct 2026 Also said in 2 more episodes
“We see that kids blame themselves. They think it's because they're bad. A lot of times there's confusion mixed up if there was any experience that was exciting for them, which is a common aspect of these traumas”
21:07Understanding Trauma and PTSD, Diagnosis and Dissociation | Episode 21Apr 2025 “the self-blaming, it'll look different and is different for adults, too, right? You'll see people with unrealistic self-blame like their parent was dying of cancer. They still feel like they could have done more somehow, even if they're there every minute of every day, taking them to every appointment”
22:08Understanding Trauma and PTSD, Diagnosis and Dissociation | Episode 21Apr 2025 Criterion E is a change in the threat system: irritability and anger outbursts with little provocation, reckless or self-destructive behavior, hypervigilance, exaggerated startle, concentration problems and sleep disturbance. The hypervigilance is threat detection, not generalized anxiety and not the paranoia of psychosis, though it can sound the same if you stay on the surface.
“people seem to be just constantly on the elevated threat level. Okay. Difficult to relax, can't relax, but not in a generalized anxiety fashion, in a threat detection fashion, and not the paranoia of psychosis either, though it often can sound the same if you stay on the surface with these people”
29:30Trauma and PTSD: How the DSM Criteria Actually Help Us Understand What’s Going OnOct 2026 Also said in 3 more episodes
“finally, the threat system of your body seems to change as well, okay? The hypervigilance”
28:25Understanding Trauma and PTSD, Diagnosis and Dissociation | Episode 21Apr 2025 “Difficult to relax, can't relax, but not in a generalized anxiety fashion, in a threat detection fashion, and not the paranoia of psychosis either, though. It often can sound the same if you stay on the surface with these people”
28:37Understanding Trauma and PTSD, Diagnosis and Dissociation | Episode 21Apr 2025 “irritability and anger outbursts with little or no provocation, reckless or self-destructive behavior, hypervigilance, exaggerated startle, concentration problems, and sleep disturbances”
29:55Understanding Trauma and PTSD, Diagnosis and Dissociation | Episode 21Apr 2025 You need a temporal relationship and sequence between the traumas and the syndrome, because every one of these symptoms shows up in other conditions too.
“You need to find a temporal relationship and a sequence between this syndrome and those traumas. Why? Because as you can expect, after having gone through all of these criteria, these are all symptoms and impairments that are commonly seen in other conditions as well”
43:20Trauma and PTSD: How the DSM Criteria Actually Help Us Understand What’s Going OnOct 2026 Also said in 1 more episode
“You need to find a temporal relationship and a sequence between this syndrome and those traumas. Why? Because, as you can expect, after having gone through all of these criteria, these are all symptoms and impairments that are commonly seen in other conditions as well”
41:29Understanding Trauma and PTSD, Diagnosis and Dissociation | Episode 21Apr 2025 In the first month, PTSD symptoms without the full syndrome are acute stress disorder. They often get better on their own, but being stuck with them is a sign to seek treatment.
“It's normal to have symptoms of PTSD without the full syndrome in that first month. It's called acute stress disorder. And The symptoms can even get better on their own and often do”
45:54Trauma and PTSD: How the DSM Criteria Actually Help Us Understand What’s Going OnOct 2026 Also said in 1 more episode
“It's called acute stress disorder. And The symptoms can even get better on their own and often do. But if you are noticing yourself stuck with the symptoms, suffering from the symptoms, they're causing you problems, that's a sign to seek treatment diagnosis”
44:07Understanding Trauma and PTSD, Diagnosis and Dissociation | Episode 21Apr 2025 Different criteria dominate in different patients: for some it is all hyperarousal, for others negative cognition and mood.
“for certain patients, different criteria for PTSD take predominance over other ones. So you can see patients with like, you know, it's all hyperarousal and it's very, very apparent. For other patients, it's like the negative cognition and mood is really the predominant thing”
46:24Trauma and PTSD: How the DSM Criteria Actually Help Us Understand What’s Going OnOct 2026 Also said in 1 more episode
“for certain patients, different criteria for PTSD take predominance over other ones. Um, so you can see patients with like, you know, it's all hyper arousal and it's very, very apparent for other patients. Uh, it's like the negative cognition and mood is really the predominant thing that you see with patients”
44:33Understanding Trauma and PTSD, Diagnosis and Dissociation | Episode 21Apr 2025 A simple approach: is there PTSD or not? If there is, most of the other problems get subsumed under PTSD.
“my approach is simply is there ptsd or not if there's ptsd that's ptsd to me and we're going to subsume most of those problems under ptsd”
43:55CPTSD vs BPD: How to Think About the Difference and What to Do About ItMar 2026
Complex PTSD
DSM-5 PTSD more or less covers what ICD-11 calls complex PTSD, so define your terms before debating.
“PTSD as defined by the DSM-5 is different than PTSD that is defined by the ICD-11. Baseline PTSD in the DSM-5 essentially more or less covers what is actually called complex PTSD in the ICD-11”
3:01CPTSD vs BPD: How to Think About the Difference and What to Do About ItMar 2026 Do not call it complex PTSD just because someone has a bunch of little-t traumas in their history.
“What I'm not going to do is I'm not going to say that someone has complex PTSD or when they simply have a bunch of little t traumas in their history”
23:06CPTSD vs BPD: How to Think About the Difference and What to Do About ItMar 2026 A mnemonic: PTSD is FEAR (fright, exposure, avoidance, re-experiencing), and complex PTSD is BAD FEAR, adding betrayal, affect regulation and developmental impact.
“it's fright, exposure, avoidance, and re-experiencing. And then CPTSD is bad fear. So that adds betrayal, affect regulation, and developmental impact”
24:03CPTSD vs BPD: How to Think About the Difference and What to Do About ItMar 2026
What it gets confused with
The primary mimic is persistent or major depression. Several core criteria resemble a depressive episode, and not everyone knows to disclose, or is comfortable disclosing, their traumas.
“this is why I think that the primary mimic of PTSD, the thing that PTSD gets misdiagnosed as the most is persistent depression or major depression”
20:14Trauma and PTSD: How the DSM Criteria Actually Help Us Understand What’s Going OnOct 2026 Also said in 2 more episodes
“the primary mimic of PTSD, the thing that PTSD gets misdiagnosed as the most is persistent depression or major depression. And then there's the spiritual stuff. There's blaming yourself in a way that just isn't objectively accurate for your traumas or what's going on with you”
20:07Understanding Trauma and PTSD, Diagnosis and Dissociation | Episode 21Apr 2025 “PTSD and trauma disorders can closely resemble and mimic depressive disorders. Several of even the core diagnostic criteria in the DSM match or at least mimic aspects of major depressive episodes. So be careful. Not everyone is comfortable with or even knows to be disclosing their DSM criteria traumas”
7:37Treating Depression: Practical Tips & Pearls for Anti-Depressant MedicationsJan 2025 People with PTSD tell you they are depressed, stuck in negative emotions and not doing what they used to, but often they do not look depressed. A classical, more biological depression looks different even when life is going OK.
“people with PTSD, they show up, they tell you they're depressed, they tell you they're stuck in negative emotions. They tell you they're not doing the same things they used to do. They don't look depressed a lot of the time, okay”
24:15Trauma and PTSD: How the DSM Criteria Actually Help Us Understand What’s Going OnOct 2026 Also said in 2 more episodes
“one of the more reliable, though of course it's not 100% reliable, ways to tell the difference is that people with PTSD, they show up, they tell you they're depressed, they tell you they're stuck in negative emotions, they tell you they're not doing the same things they used to do, they don't look depressed a lot of the time”
23:12Understanding Trauma and PTSD, Diagnosis and Dissociation | Episode 21Apr 2025 “someone with a classical, more biological depression... You know, the kind that can happen to people in episodes lasting at least two weeks in a row. And even if their life is pretty much going OK. They look different”
24:44Understanding Trauma and PTSD, Diagnosis and Dissociation | Episode 21Apr 2025 Depression alone is unlikely to bring lots of nightmares, fear responses, startle, irritability, anger outbursts and fearful avoidance. Seeing those, suspect trauma.
“if it's depression alone, it's unlikely to see a large amount of nightmares, fear response, Startle, Irritability, Anger Outbursts, and Fearful Avoidance”
29:58What Patients Should Know When Diagnosed With DepressionSep 2026 PTSD is the great imitator and can feel like mania or hypomania. People with a severe trauma disorder can be so hypervigilant that they do not sleep for days, so do not inappropriately treat it as bipolar disorder.
“PTSD is like the great imitator for psychiatry. And you do see patients all the time that it's so confusing because what you're seeing in front of you feels like a mania or hypomania”
49:49How to Diagnose Bipolar Disorder: The Interview Framework That Beats Screening QuestionsFeb 2026 Also said in 2 more episodes
“Another major mimic that I think you really want to make sure you're not inappropriately treating is severe insomnia related to a trauma disorder. OK, people with a severe trauma disorder can be in such a hypervigilant state that they won't sleep for even a couple of days in a row”
49:15How to Diagnose Bipolar Disorder: The Interview Framework That Beats Screening QuestionsFeb 2026 “I find that severe PTSD can be reported as something that really sounds like mania or hypomania. Some patients will talk about being awake for days”
18:17PTSD Medications: Integrating Pharmacotherapy, Therapy, and the Treatment Frame | Episode 22Apr 2025 Anxiety and specific phobias are easily confused with it, and problems with concentration, focus and memory can pass for neurodevelopmental or neurocognitive disorders. Concentration trouble is a core PTSD criterion.
“in PTSD, the problems of concentration is a core diagnostic criteria. It is part of the symptom set. You see it all the time. And again, the body and the mind in trauma disorder is at a high level of threat”
28:35ADHD Is Not the Only Diagnosis: Differential and Diagnostic HierarchyNov 2025 Also said in 1 more episode
“Sometimes the severe agitation and problems with sleep that people with PTSD have can look like or sound like mania or hypomania. Obviously, anxiety and specific phobias can be easily confused with PTSD, right? Problems with concentration, focus, memory can be confused for neurodevelopmental or neurocognitive disorders”
42:07Understanding Trauma and PTSD, Diagnosis and Dissociation | Episode 21Apr 2025 Many patients who come in with TikTok phrases like rejection sensitive dysphoria and 'I can't concentrate' match the wording of the PTSD criteria far better than the ADHD criteria.
“a lot of people come in with like TikTok phrases of like, I have rejection, sensitivity, dysphoria, I can't concentrate. And if you walk through, if you pull up the DSM criteria, The way they word it matches the experience a lot more than the ADHD criteria”
32:21ADHD Is Not the Only Diagnosis: Differential and Diagnostic HierarchyNov 2025 A lot of voice hearing is not a schizophrenia spectrum disorder but comes from cultural background, a personality trait or syndrome, or PTSD. In severe PTSD, apparent voices, noises or shadows flitting past are often a dissociative process, not psychotic features.
“a lot of people who might be identified by some clinicians as having some kind of an odd psychotic disorder are actually experiencing dissociative reactions. A lot of voice hearing is not the product of a schizophrenia spectrum disorder”
44:35Trauma and PTSD: How the DSM Criteria Actually Help Us Understand What’s Going OnOct 2026 Also said in 2 more episodes
“a lot of the time, the experiences of hearing apparent voices, noises, or seeing things, even flits of shadows going past that you see in the severe PTSD is a dissociative process and not properly with psychotic features process”
17:11PTSD Medications: Integrating Pharmacotherapy, Therapy, and the Treatment Frame | Episode 22Apr 2025 “A lot of voice hearing is not the product of a schizophrenia spectrum disorder. A lot of voice hearing experience is the product of a cultural background, a personality trait or syndrome, or PTSD. You can experience flashbacks, dissociations as a parent voices, even when it doesn't seem to be directly related to the incident trauma”
42:54Understanding Trauma and PTSD, Diagnosis and Dissociation | Episode 21Apr 2025 Reserve 'delusions', 'hallucinations', 'negative symptoms' and 'disorganization' for primary psychotic disorders. For trauma and personality syndromes say reported voices, fear or hypervigilance, and overvalued idea or inflexible belief.
“i recommend that we as a field we stop using terms delusions, hallucinations, negative symptoms, disorganized behaviors or speech. I think we should stop using those unless we can attribute them to a primary quote-unquote psychotic disorder”
5:41What is Psychosis? Look at the DSM, Common Mimics, and a Framework for the DifferentialJan 2026 Also said in 1 more episode
“We can call it voice hearing, right? Reported voices instead of hallucinations. We can call it fear or hypervigilance instead of paranoia. And we should call it an overvalued idea or inflexible belief instead of delusion”
25:51What is Psychosis? Look at the DSM, Common Mimics, and a Framework for the DifferentialJan 2026 A high degree of anxiety does not equal GAD; PTSD is one of several sources. New 'anxiety' can turn out to be a trauma and stressor-related disorder from actively living in an abusive environment.
“They say, if this patient has a generally high degree of anxiety, they have generalized anxiety disorder. Not true, folks, not true”
25:39Understanding Anxiety, GAD, and Treatments of AnxietyJun 2025 Also said in 1 more episode
“if you looked at his history, it was because he was actively living in an abusive environment and that the symptoms that he was having, new onset, were not from a trait anxiety, but were basically a trauma stressor related disorder”
54:11Understanding Anxiety, GAD, and Treatments of AnxietyJun 2025 The picture can be framed as major depression plus PTSD with an agitated state, plus generalized anxiety disorder with an anxious state, plus attention deficit disorder with irritable phases, plus borderline personality disorder with phases of varied symptoms.
“major depression plus PTSD with an agitated state, major depression plus generalized anxiety disorder with an anxious state, major depression with attention deficit disorder with irritable phases, major depression with borderline personality disorder with phases of variety of symptoms”
35:29How to Diagnose Bipolar Disorder with Dr. Phelps: Hypomania, Mixed States & the Clues DSM MissesSep 2026Guest episode Trauma is very common, but true PTSD, with the physiologic reactivity and burden of re-exposure, is found in only a subset of people who had a traumatic experience.
“having true PTSD in terms of the physiologic reactivity and the burden of re-exposure and all that that goes with true PTSD is not that common when you look at people who've had a traumatic experience. It's only a subset who get the PTSD symptoms that go with it”
32:37Dr. Jim Phelps’ Bipolar Treatment Tier List: Lessons from 30+ Years in PsychiatryJul 2026Guest episode A personality disorder does not rule out other diagnoses. In uncomplicated personality cases, PTSD is one of the most common, since trauma matters so much to borderline conditions.
“plenty of people do. i find that for uncomplicated personality type cases the most common axis one issues are ptsd naturally trauma being important for much of the etiology of borderline conditions and maybe a dysthymic disorder”
35:58Treating Borderline Personality Effectively aka How To Be A Good Psychiatrist Through GPMMay 2025
Interviewing about trauma
It is very easy to miss trauma without a good CAPS-5 style screen, and even then patients may forget to tell you. They are not hiding it: talking about it is upsetting and dysregulating, and part of the memory seems dissociated.
“they might forget to tell you. I've had that happen multiple times in multiple cases. It seems to be that part of the memory seems to be dissociated”
25:12Trauma and PTSD: How the DSM Criteria Actually Help Us Understand What’s Going OnOct 2026 Also said in 2 more episodes
“if you don't get a good trauma screen, like a CAPS-5 style trauma screen of a patient, it is very, very, very easy to miss trauma. People don't want to talk about their traumas. It's upsetting. It's dysregulating to talk about traumas”
29:37ADHD Is Not the Only Diagnosis: Differential and Diagnostic HierarchyNov 2025 “they might forget to tell you. I've had that happen multiple times in multiple cases. It seems to be that part of the memory seems to be dissociated”
24:15Understanding Trauma and PTSD, Diagnosis and Dissociation | Episode 21Apr 2025 Dissociation of memory is common, especially in moderate to severe cases, so patients may not be able to tell an organized story. Often they have no idea their hyperarousal or flashbacks are linked to a past event.
“dissociation of memory is very common. And as a result, especially in people with more moderate to severe cases or with other existing comorbidities and vulnerabilities, their ability to either tell you a organized story of what has”
34:27Understanding Trauma and PTSD, Diagnosis and Dissociation | Episode 21Apr 2025 Also said in 1 more episode
“the more extreme responses and the hyper arousal and the intrusive flashbacks, people commonly have no connection. link to what those experiences are it's not all the time but often they have no idea that it's linked to some past event”
36:41Understanding Trauma and PTSD, Diagnosis and Dissociation | Episode 21Apr 2025 Do not take this as an invitation to uncover hidden memories. Clinicians can induce memories of trauma and abuse by suggesting them. Do not suggest; simply look.
“Don't take this as an invitation, by the way, to get into the camp where you think you can uncover all these memories. Be careful about that. If you look at the research of Elizabeth Loftus, you, the clinician, can absolutely endure”
36:45Trauma and PTSD: How the DSM Criteria Actually Help Us Understand What’s Going OnOct 2026 Also said in 1 more episode
“If you look at the research of Elizabeth Loftus, you, the clinician, can absolutely induce memories of traumas and abuse in your life. unknowing patients by suggesting them. Don't suggest that things have happened. Simply look to see if something has happened”
35:02Understanding Trauma and PTSD, Diagnosis and Dissociation | Episode 21Apr 2025 Look for an unexplained decline instead: 'You told me about some traumas and a recovery, yet three years ago you started really declining and did not mention anything that year. What was stressing you out?'
“I said, you know, it's a little unusual. You told me about some traumas and you told me about a recovery from it. Yet, you know, three years ago, you started really declining and you didn't tell me about anything happening that year. What was stressing you out that year”
37:35Trauma and PTSD: How the DSM Criteria Actually Help Us Understand What’s Going OnOct 2026 Also said in 1 more episode
“I didn't say... You must have been abused or traumatized during that time. No, I said, you know, it's a little unusual. You told me about some traumas and you told me about a recovery from it. Yet, you know, three years ago, you started really declining and you didn't tell me about anything happening that year”
35:36Understanding Trauma and PTSD, Diagnosis and Dissociation | Episode 21Apr 2025 Have them walk you through an ordinary day in the period before the problem. That narrative can show things like intermittent freezing that they would never put in those words.
“what kind of problems were you having at that time in the period leading up to the offense? And so I had her talk about her day and she talked about how she didn't put it in these words, but she basically gave a narrative description of intermittently freezing and not being able to respond throughout the day”
39:35Trauma and PTSD: How the DSM Criteria Actually Help Us Understand What’s Going OnOct 2026 Also said in 1 more episode
“I simply asked, what kind of problems were you having at that time in the period leading up to the offense? And so I had her talk about her day”
37:42Understanding Trauma and PTSD, Diagnosis and Dissociation | Episode 21Apr 2025 Avoid dysregulating the patient: a diagnosis is not psychotherapy. Tell them you are not trying to pull them back into trauma memories, you need to reach a medical diagnosis, and they can ask for a break, pause or stop.
“I will tell patients, listen, we're not here to get you sucked back into trauma memories. I'm trying to reach a medical diagnosis today, and so we will have to go over some difficult stuff. But tell me if you need a break, if we need to pause or stop, or if you're not ready to talk about something”
55:11Trauma and PTSD: How the DSM Criteria Actually Help Us Understand What’s Going OnOct 2026 Also said in 1 more episode
“you should avoid dysregulating the patient in the interviews, right? You're not doing a psychotherapy when you're doing a diagnosis. You're just trying to get information. And I will tell patients, listen, we're not here to get you sucked back into trauma memories”
53:09Understanding Trauma and PTSD, Diagnosis and Dissociation | Episode 21Apr 2025 Monitor their state question by question. Missing growing irritation can end in a patient getting very emotional and angry at you.
“she was slightly getting more and more irritated by my questions because I think it was that they were triggering. And when I finally got to something that was really, really upsetting for her and because I wasn't doing a great job monitoring. She got really emotional, she got angry at me”
56:19Trauma and PTSD: How the DSM Criteria Actually Help Us Understand What’s Going OnOct 2026 Also said in 1 more episode
“I wasn't doing a good job monitoring her state on the questions. And after looking back, when I thought about what was going on, she was slightly getting more and more irritated by my questions because I think it was”
54:20Understanding Trauma and PTSD, Diagnosis and Dissociation | Episode 21Apr 2025 When it happens, name it ('it seems like I'm irritating you, and I don't blame you, these are annoying questions'), explain why you ask, and give back the agency to stop. You do not need all hundred answers today: the fact that something cannot be gathered now is information, and the black box can be filled in later.
“I think that's a big part is giving them back the agency saying like, I acknowledge these questions are distressing. Any point you want to stop. And also not as a practitioner, like in residency, it's like I needed to gather these hundred questions and all the answers”
58:03Trauma and PTSD: How the DSM Criteria Actually Help Us Understand What’s Going OnOct 2026 Also said in 2 more episodes
“I notice that as we're doing this, it seems like I'm irritating you and I don't blame you for that. These are annoying questions. I'm sure you've been asked about them a lot and might not seem clear right away why I'm asking so much or in this way”
55:32Understanding Trauma and PTSD, Diagnosis and Dissociation | Episode 21Apr 2025 “there's information packed in the fact that that information can't be gathered now and it can the black box can get filled in later”
56:31Understanding Trauma and PTSD, Diagnosis and Dissociation | Episode 21Apr 2025
Treatment approach
First line is trauma-focused psychotherapy. Medication is an alternative for someone who truly does not want therapy, not a replacement for it.
“First line is trauma-focused psychotherapy. Medications are an alternative if a patient truly does not want therapy but shouldn't be viewed as therapy or medication”
5:14PTSD Medications: Integrating Pharmacotherapy, Therapy, and the Treatment Frame | Episode 22Apr 2025 Treatment starts with trust, safety and stabilization: the patient cannot be so dysregulated, or so on watch for danger, that they cannot think.
“the first stage of the treatment you need to start with trust safety and stabilization okay the patient can't be overly dysregulated okay they can't be so looking out for danger that they can't think”
40:21PTSD Medications: Integrating Pharmacotherapy, Therapy, and the Treatment Frame | Episode 22Apr 2025 Trust is the fundamental thing to establish first, in any treatment but especially trauma. That does not mean believing everything the patient says; it means demonstrating that you and the treatment are trustworthy, because early trauma teaches people that nothing is.
“When I say that trust is so important in the treatment, I don't mean that you, the clinician, trust everything the patient says. I mean that you need to demonstrate that the treatment and that you, the clinician, are trustworthy of the patient”
49:49Trauma and PTSD: How the DSM Criteria Actually Help Us Understand What’s Going OnOct 2026 Also said in 2 more episodes
“trust is sort of the fundamental thing that you need to establish first, really for any treatment, but especially in the treatment of trauma”
2:09PTSD Medications: Integrating Pharmacotherapy, Therapy, and the Treatment Frame | Episode 22Apr 2025 “i don't mean that you the clinician trusts everything the patient says i mean that you need to demonstrate that the treatment and that you the clinician are trustworthy of the patient because after traumas especially early traumas”
47:59Understanding Trauma and PTSD, Diagnosis and Dissociation | Episode 21Apr 2025 Trust and safety come from regularity and a solid, unwavering understanding of what you are there to do.
“how do you establish trust and safety in a treatment as a clinician? It's about regularity and a really solid and unwavering understanding of what you're there to do”
43:12PTSD Medications: Integrating Pharmacotherapy, Therapy, and the Treatment Frame | Episode 22Apr 2025 Recognize the PTSD syndrome specifically, then give PTSD-specific psychoeducation and treatment recommendations. When it is accurately recognized and people are told what is happening and how to solve it, they get better a lot faster.
“the majority of people who experience a criterion A trauma don't go on to develop PTSD. And then it's really necessary to both... Specifically recognize the PTSD syndrome and then give the psychoeducation and treatment recommendations that you need to get better from that”
53:43Trauma and PTSD: How the DSM Criteria Actually Help Us Understand What’s Going OnOct 2026 Also said in 2 more episodes
“when it's accurately recognized and you actually tell people what's happening to them and how to solve that, people get better a lot faster and a lot better”
58:33Trauma and PTSD: How the DSM Criteria Actually Help Us Understand What’s Going OnOct 2026 “it's kind of inadequate conceptualization to think that everything comes from trauma. Again, the majority of people who experience a criterion, a trauma don't go on to develop PTSD. And then it's really necessary to both specifically recognize the PTSD syndrome and then give the psychoeducation and treatment recommendations that you need to get better from that”
51:46Understanding Trauma and PTSD, Diagnosis and Dissociation | Episode 21Apr 2025 Recommend any named, specific trauma psychotherapy: CPT, trauma-focused CBT, even EMDR.
“anything that is a named and specific psychotherapy for trauma, I would generally recommend. That includes the IP, you know, the CPTs, right? the CBT traumas, even EMDR”
55:16Insomnia and Sleep Medications in PsychiatryDec 2024 Psychodynamic work matters more for early-onset trauma, where pure CBT struggles.
“psychodynamic being more important for early onset traumas. I feel like that's an area where going pure CBT struggles. You know, there's actually a type of psychotherapy that seems to be more intended for people with multi-traumas”
28:13Trauma and PTSD: How the DSM Criteria Actually Help Us Understand What’s Going OnOct 2026 Trauma disorders respond better to trauma therapy. Until upstream trauma or personality problems are addressed, a medication may work for a month or two and then poop out.
“trauma disorders respond better to trauma therapy. And that personality problems or developmental interpersonal problems respond better to changes and exercises in how you conduct your relationships and with who”
28:37What Patients Should Know When Diagnosed With DepressionSep 2026 Also said in 1 more episode
“And until you address those upstream problems, you're going to continue to see that depression. So yes, maybe a medication will work for a month or two, but eventually it's going to poop out”
29:20What Patients Should Know When Diagnosed With DepressionSep 2026 Where trauma therapy is out of reach, traditional spiritual practice and a spiritual community, with safe, trusting relationships and support, have brought good improvement, for free.
“I have seen a lot of good clinical improvement from people who sought out traditional spiritual practices, engaging with the spiritual community, finding safe and trusting relationships and support in that method, which was free to them”
48:19Trauma and PTSD: How the DSM Criteria Actually Help Us Understand What’s Going OnOct 2026 Also said in 1 more episode
“i have seen a lot of good clinical improvement from people who sought out traditional spiritual practices engaging with the spiritual community finding safe and trusting relationships and support in that method um which was free to them”
46:28Understanding Trauma and PTSD, Diagnosis and Dissociation | Episode 21Apr 2025 Have the patient identify for themselves something objectively safe with people they trust, who are at least basically not aggressive and OK to spend time with.
“the number one thing is I want them to identify for themselves something that is objectively safe, that they trust effectively. The people to be at least basically not aggressive and basically OK to spend time with”
22:53Beyond Medications: The Best Lifestyle Treatments for Mental HealthFeb 2025 Mindfulness gets an asterisk: on its own it can harm some patients. Lean on grounding techniques instead, because mindfulness can become very stressful when your world is full of threat.
“I'm going to give it an asterisk because mindfulness on its own can actually be harmful to the patient. It really depends on the particular patient”
24:10Mindfulness in Psychiatry: How to Teach It as a Clinical Treatment SkillMay 2026 Also said in 1 more episode
“I focus more on grounding techniques rather than mindfulness proper because the mindfulness can become a very stressful thing when the world you're living in is full of threats and danger”
24:30Mindfulness in Psychiatry: How to Teach It as a Clinical Treatment SkillMay 2026 Goals of treatment: maintain safety, reduce distress from intrusive re-experiencing (nightmares, flashbacks, unwanted thoughts), and reduce hyperarousal.
“maintain safety is a huge one reducing symptoms of distress related to intrusive re-experiencing talking about nightmares flashbacks unwanted thoughts all that good stuff reducing hyper arousal”
3:10PTSD Medications: Integrating Pharmacotherapy, Therapy, and the Treatment Frame | Episode 22Apr 2025
Medications
Medications are huge for stage one: stabilization, trust and safety.
“We're going to get slightly more detailed into the Genet three-stage model for trauma treatment. Medications, in my opinion, are huge for stage one, which is stabilization, trust, safety”
2:52PTSD Medications: Integrating Pharmacotherapy, Therapy, and the Treatment Frame | Episode 22Apr 2025 In moderate to severe cases, with clear-cut disruption of work or really disrupted sleep, medication alongside trauma treatment is not optional.
“I don't necessarily see the medications as optional in moderate to severe cases. What do I mean by that? I think if you're seeing enough disruption of work functioning clear-cut or just a really disrupted sleep, I think it's actually pretty important to medicate alongside the trauma treatment”
5:48PTSD Medications: Integrating Pharmacotherapy, Therapy, and the Treatment Frame | Episode 22Apr 2025 The VA evidence chart lists something like 20 medications from four or five classes, all with poor evidence.
“it's pretty much, I don't know, something like 20 different types of medications of maybe four to five classes. All of them are poor evidence”
6:41PTSD Medications: Integrating Pharmacotherapy, Therapy, and the Treatment Frame | Episode 22Apr 2025 The plain algorithm for clean-cut patients: an SSRI, then another SSRI, then add a second-generation antipsychotic.
“start with an SSRI. If that doesn't work, switch to another SSRI. And I'm talking about without any nuance involved in these, you know, like your clean cut patients. SSRI, if that doesn't work, switch to another SSRI. If that doesn't work, you can add a second-gen antipsychotic”
7:32PTSD Medications: Integrating Pharmacotherapy, Therapy, and the Treatment Frame | Episode 22Apr 2025 Sertraline is preferred. Paroxetine is avoided by some for weight gain, though it works quickly and is a sleeper as well as an antidepressant, a lot of bang for the buck in one tablet.
“its efficacy, it works quickly, you know, and it's a Sleeper on top of being an antidepressant class medication. You get a lot of bang for your buck there. All in one tablet. Easy to dose. There's a long-acting form and a short-acting form”
28:04Antidepressant Tier List: Psychiatrists Rank Depression Medications for MDDMay 2026 Also said in 1 more episode
“I do like to use sertraline. I try to avoid Paxil because I don't like to give people weight gain, as you know, with medications”
4:50PTSD Medications: Integrating Pharmacotherapy, Therapy, and the Treatment Frame | Episode 22Apr 2025 When patients like their sleep support, do not neglect pushing the SSRI to an adequate dose. You will see benefits; it is just slower than getting someone sleeping.
“Don't neglect pushing that SSRI to an adequate dose. You will see benefits from that. It's just a slower acting one, generally speaking, than getting someone sleeping right away”
19:58PTSD Medications: Integrating Pharmacotherapy, Therapy, and the Treatment Frame | Episode 22Apr 2025 Mirtazapine may be one of the best choices if you do not mind the appetite increase and weight gain.
“I forgot to mention mirtazapine. It's a very good choice if you don't mind the appetite increase in weight gain. It may be, in my opinion, one of the best choices as long as there's no concern about weight gain”
33:23PTSD Medications: Integrating Pharmacotherapy, Therapy, and the Treatment Frame | Episode 22Apr 2025 Antipsychotics help most when the PTSD is severe and comes with a real comorbid major depressive or bipolar-type mood disorder. If it looks like depression with psychotic features alongside PTSD, consider the agents with bipolar depression efficacy.
“Where I have found the antipsychotic to be very helpful is when the PTSD is of such severity and is accompanied by some kind of a true major depressive or even bipolar type mood, disorder, that they have that alongside it, a real comorbidity”
14:43PTSD Medications: Integrating Pharmacotherapy, Therapy, and the Treatment Frame | Episode 22Apr 2025 Also said in 1 more episode
“if you see something that looks like MDV with psychotic features alongside the PTSD, don't be afraid to consider the agents for bipolar depression efficacy as well”
15:48PTSD Medications: Integrating Pharmacotherapy, Therapy, and the Treatment Frame | Episode 22Apr 2025 Buspirone can be adequately sedating at a high dose for some. Start at a minimum of 15 mg in the morning and 15 mg at night, and loading most of it at night is fine if tolerated.
“You can get away with buspar, forgot to mention. In some patients, it's adequately sedating at a high dose”
16:51PTSD Medications: Integrating Pharmacotherapy, Therapy, and the Treatment Frame | Episode 22Apr 2025 Also said in 1 more episode
“I start minimum 15 milligrams in the morning, 15 milligrams at night. I'm not terribly opposed to loading most of the dose at night if it's tolerated”
20:43PTSD Medications: Integrating Pharmacotherapy, Therapy, and the Treatment Frame | Episode 22Apr 2025 Traditional mood stabilizers have not been terribly helpful. Topiramate and gabapentin are more usable.
“They've talked about using mood stabilizers. I have not found that to be terribly helpful. Only the non-traditional mood stabilizers, not really mood stabilizers, Topamax and Gabapentin, I think, are more usable”
19:29PTSD Medications: Integrating Pharmacotherapy, Therapy, and the Treatment Frame | Episode 22Apr 2025 When the picture is likely trauma or personality and still undifferentiated, start with smaller things like gabapentin, hydroxyzine, buspirone or propranolol rather than serotonin-based drugs, because of the risk of agitating an unrecognized bipolar disorder.
“Not SSRIs, you know, not necessarily serotonin-based medications primary because of the risk of agitating bipolar disorders because in undifferentiated patient, we don't know which is which, but just smaller things, you know. your gabapentin hydroxyzine your uh buspirone uh propranolol”
28:35What is Psychosis? Look at the DSM, Common Mimics, and a Framework for the DifferentialJan 2026 Avoid benzodiazepines: no clear benefit, they could worsen PTSD, and they impair learning in therapy. They suppress symptoms and slow recovery, which matches the anti-psychiatry accusation.
“We should be avoiding benzodiazepines. And that's because there's an absence of clear benefit. It could worsen the PTSD. And the big problem is it impairs learning in therapy”
8:10PTSD Medications: Integrating Pharmacotherapy, Therapy, and the Treatment Frame | Episode 22Apr 2025 Also said in 1 more episode
“something like a benzodiazepine is going to slow down recovery, right? Yes, you're suppressing the symptoms, but that one really does kind of match the anti-psychiatry accusations”
8:37PTSD Medications: Integrating Pharmacotherapy, Therapy, and the Treatment Frame | Episode 22Apr 2025 After some stability, roughly a year of remission (an arbitrary rule, with no data), you can at least peel off some of the medication.
“after some degree of stability, we don't have any data on this. I just do the arbitrary one year of remission thing. You can definitely at least peel off some of this medication”
31:46PTSD Medications: Integrating Pharmacotherapy, Therapy, and the Treatment Frame | Episode 22Apr 2025
Sleep and nightmares
Treat the sleep first. If someone with PTSD is seeing a psychiatrist rather than remitting on their own or with a therapist, it is usually because sleep is severely disrupted, and the disorder and the poor sleep feed each other. Waiting weeks on an SSRI alone is less effective.
“if somebody has PTSD and they're coming in to see the psychiatrist and they're not just either remitting on their own slowly or working through it with a counselor or a psychotherapist, it's because the sleep is severely disrupted”
9:53PTSD Medications: Integrating Pharmacotherapy, Therapy, and the Treatment Frame | Episode 22Apr 2025 Also said in 2 more episodes
“the disorder makes the sleep worse and then the worsening sleep makes the disorder worse. So if you get that on track, a lot of times you'll see just downstream improvements”
11:16PTSD Medications: Integrating Pharmacotherapy, Therapy, and the Treatment Frame | Episode 22Apr 2025 “So you really, really need to treat the sleep first, in my opinion, for the trauma disorder. And now you could wait several weeks sometimes or longer and try to rely solely on your SSRI. I think that's less effective and you don't need to do that”
52:05Insomnia and Sleep Medications in PsychiatryDec 2024 For sleep, usually trazodone or gabapentin; hydroxyzine is fine too. Avoid anticholinergics like diphenhydramine if you can.
“I give some kind of a medication. It's usually trazodone or gabapentin. Hydroxyzine is just fine, too. I avoid anticholinergics like Benadryl, if I can help it”
11:41PTSD Medications: Integrating Pharmacotherapy, Therapy, and the Treatment Frame | Episode 22Apr 2025 Prazosin shows a lot of clinical efficacy despite mixed evidence; just watch blood pressure. The dose depends on the individual: the study in mostly male veterans went up to 7 or 8 mg.
“Don't forget that how much prazosin you're supposed to use depends a lot. on the individual, right? When they did the study on male veterans, mostly male veterans, I believe they were going up to seven or eight milligrams, pretty high”
12:08PTSD Medications: Integrating Pharmacotherapy, Therapy, and the Treatment Frame | Episode 22Apr 2025 Also said in 1 more episode
“Prazosin, as you know, even with this mixed evidence, I see a lot of clinical efficacy. Just watch that blood pressure”
52:26Insomnia and Sleep Medications in PsychiatryDec 2024 Some prefer not to touch blood pressure right away, having found it is usually not needed.
“I personally try to avoid messing around with the blood pressure right away because I've found in my experience I don't need to”
13:13PTSD Medications: Integrating Pharmacotherapy, Therapy, and the Treatment Frame | Episode 22Apr 2025 Imagery rehearsal therapy works well for nightmares, and DBT has a good nightmare protocol.
“image rehearsal therapy for nightmares can be helpful too, which is a non-pharmacological add-on that can help”
14:02PTSD Medications: Integrating Pharmacotherapy, Therapy, and the Treatment Frame | Episode 22Apr 2025 Also said in 1 more episode
“in terms of non-medication related things, image rehearsal therapy works really well for nightmares, you know, for high functioning patients, which, you know, can be difficult. But DBT has a nice nightmare protocol”
53:38Insomnia and Sleep Medications in PsychiatryDec 2024
Voices and dissociation
Do not chase dissociative voices by pumping up the antipsychotic. It mostly does not work or just over-sedates. It is not dangerous: the target is not zero voices but less distress and better function.
“OK, don't chase that by pumping up the antipsychotic. Most of the time doesn't work or you're just over sedating them so that they don't have that anymore. It's not dangerous. The treatment target is not zero voices, noises, experiences”
32:14PTSD Medications: Integrating Pharmacotherapy, Therapy, and the Treatment Frame | Episode 22Apr 2025 Also said in 1 more episode
“I wasn't assessing voices or no voices. I was assessing the distress of the voices and how it impacted her functionality”
33:15PTSD Medications: Integrating Pharmacotherapy, Therapy, and the Treatment Frame | Episode 22Apr 2025 Advise against fighting dissociation, because fighting it seems to pull people into a generalized fear response.
“I probably advise against fighting it. Part of that fighting response seems to pull people into a generalized fear or anxiety response that might make things work”
36:27PTSD Medications: Integrating Pharmacotherapy, Therapy, and the Treatment Frame | Episode 22Apr 2025 Many people fear they are completely out of control or almost unconscious during dissociation, which is generally not true.
“a lot of people are also afraid that they're completely out of control. or can't do anything at all, or are almost unconscious during dissociation, which is not generally true”
38:10PTSD Medications: Integrating Pharmacotherapy, Therapy, and the Treatment Frame | Episode 22Apr 2025
In medication management
Keep medication management separate from psychotherapy, even if you can do both.
“I do recommend that medication management actually take place separately from psychotherapy, even if you're capable of doing both”
47:45PTSD Medications: Integrating Pharmacotherapy, Therapy, and the Treatment Frame | Episode 22Apr 2025 Do not try trauma processing in a medication visit. It is not appropriate, and you do not want to teach patients to be afraid of their trauma memories.
“don't try the trauma process when you're doing medication management. It's not appropriate. You don't want to teach patients to be afraid of the trauma memories”
53:55PTSD Medications: Integrating Pharmacotherapy, Therapy, and the Treatment Frame | Episode 22Apr 2025 When a patient goes into therapy mode, thank them, and say you want to use the time to talk about what helps you decide about their medications.
“I appreciate that. At the same time, I want to use the time productively. I want to talk about the things that help me figure out what to do with medications for you”
55:26PTSD Medications: Integrating Pharmacotherapy, Therapy, and the Treatment Frame | Episode 22Apr 2025
Talking to patients
Tell every patient: this medication will not solve your problems or take away what happened, but it will help. It supports the primary treatment, which is the psychotherapy and what you do in your life.
“I tell every patient, this medication is not going to solve your problems. This medication is not going to take over, take over, take away the fact that you had these traumas, but it'll help”
3:50PTSD Medications: Integrating Pharmacotherapy, Therapy, and the Treatment Frame | Episode 22Apr 2025 Also said in 1 more episode
“I tell all the patients with trauma disorders that the medication is supporting their treatment but that the primary treatment is the things that they're doing in their lives and the psychotherapy if they're willing to engage with it”
54:13Insomnia and Sleep Medications in PsychiatryDec 2024 A white coat and stethoscope do not earn these patients' trust. Acknowledge that it is OK not to trust you, and work for it.
“just because you have a white coat and a stethoscope, you do not deserve the trust of these patients. And it really needs to be earned. It needs to be acknowledged that it's okay to not trust me”
51:08Trauma and PTSD: How the DSM Criteria Actually Help Us Understand What’s Going OnOct 2026 Also said in 1 more episode
“It needs to be acknowledged that it's okay to not trust me. And I know you have to work for it”
49:27Understanding Trauma and PTSD, Diagnosis and Dissociation | Episode 21Apr 2025 Explain that this happened both because of the traumas and because of their response: avoiding danger is rational, but it also perpetuates the problem.
“I try to make it fairly clear that this is something that has happened to them both because of the traumas that they've had and also because of the response. That it's a rational but also perpetuating response to keep avoiding danger”
21:31PTSD Medications: Integrating Pharmacotherapy, Therapy, and the Treatment Frame | Episode 22Apr 2025 People with chronic PTSD are not brats who refuse to expose themselves, or weak people.
“The people who... develop the chronic ptsd it's not because they you know are little brats who refuse to expose themselves or weak people or something like that right”
29:42PTSD Medications: Integrating Pharmacotherapy, Therapy, and the Treatment Frame | Episode 22Apr 2025 'Don't be afraid' convinces no one. Be afraid, and act in the direction of where you want to be anyway.
“Don't be afraid. Just telling people that is not going to convince them. Right. But be afraid and nonetheless act in the direction that will get you to where you want to be”
58:11Understanding Trauma and PTSD, Diagnosis and Dissociation | Episode 21Apr 2025 If someone believes poor concentration means ADHD, pull up the PTSD criteria and read criterion E with them, so it is not just you saying it is probably trauma.
“I pull up the criteria. And I say, let me just read some things and see if these are things that you resonate with. So I'm looking at criterion E. And I do that because I think it's helpful for the person to think like, this isn't just me saying like, oh, you can't concentrate. That's probably trauma”
30:32ADHD Is Not the Only Diagnosis: Differential and Diagnostic HierarchyNov 2025
Pitfalls
Trauma is over-referenced: everyone thinks everyone has trauma, and some therapists treat everything, depression included, as trauma to get out. Meanwhile PTSD is under-identified: classic cases carry a depression or substance use label and are on their thirtieth antidepressant trial.
“I saw a lot of PTSD patients or to me, their diagnosis of PTSD who carried the diagnosis of depression. And we're on their 30th trial of a new antidepressant. And, you know, they were substance use disorder and depression. It's like, no, this is a classic PTSD case”
53:15Trauma and PTSD: How the DSM Criteria Actually Help Us Understand What’s Going OnOct 2026 Also said in 2 more episodes
“i think that it's over referenced everyone thinks everyone's got trauma and that's clinically relevant but i don't think that enough people are identifying ptsd and giving the treatment recommendations specifically for ptsd”
50:46Understanding Trauma and PTSD, Diagnosis and Dissociation | Episode 21Apr 2025 “I saw a decent chunk of clinicians, therapists who think that everything is trauma. Depression is, oh, we need to get the trauma and get them up to speed on that trauma, get it out, and all the symptoms go away”
51:05Understanding Trauma and PTSD, Diagnosis and Dissociation | Episode 21Apr 2025
It also comes up on
- Complex PTSDIn the ICD, complex PTSD is PTSD plus disturbances of self-organization, which include difficulties regulating emotions.
- Complex PTSDA commonly recommended book is Complex PTSD: From Surviving to Thriving by Pete Walker, written by someone with complex PTSD.
- AntipsychoticsQuetiapine can be used in PTSD, anxiety and depression, but the weight gain, appetite, diabetes risk and sedation are massive compared with the antipsychotic benefit.
- AnxietyPTSD and OCD were anxiety disorders in DSM-III and IV and are now separate chapters, and we agree with that separation.
- Case formulationA bare label can obscure. Call it generalized anxiety disorder or PTSD and ignore the personality and developmental components that belong in the formulation, and the diagnosis robs you of vision rather than giving you clarity.
- DSM-5In DSM-III and IV, PTSD and OCD were anxiety disorders. They now have separate chapters, and we agree with that separation.
- Personality disordersSome patients use the complex PTSD label as a defense against looking at their personality dysfunction. The conversation about traits lets you open that up earlier.
- Psychiatric diagnosisA diagnosis can obscure. Simply calling it generalized anxiety disorder or PTSD and ignoring the personality, developmental and other components that belong in the formulation robs us of vision rather than giving us clarity.
From these episodes
- Diagnostic Hierarchy Explained: Why Patients Get 5 DiagnosesNov 2026 · 1 point
- Trauma and PTSD: How the DSM Criteria Actually Help Us Understand What’s Going OnOct 2026 · 37 points
- What Patients Should Know When Diagnosed With DepressionSep 2026 · 3 points
- How to Diagnose Bipolar Disorder with Dr. Phelps: Hypomania, Mixed States & the Clues DSM MissesSep 2026 · 1 point
- Dr. Jim Phelps’ Bipolar Treatment Tier List: Lessons from 30+ Years in PsychiatryJul 2026 · 1 point
- Antidepressant Tier List: Psychiatrists Rank Depression Medications for MDDMay 2026 · 1 point
- Mindfulness in Psychiatry: How to Teach It as a Clinical Treatment SkillMay 2026 · 2 points
- CPTSD vs BPD: How to Think About the Difference and What to Do About ItMar 2026 · 6 points
- How to Diagnose Bipolar Disorder: The Interview Framework That Beats Screening QuestionsFeb 2026 · 2 points
- What is Psychosis? Look at the DSM, Common Mimics, and a Framework for the DifferentialJan 2026 · 3 points
- ADHD Is Not the Only Diagnosis: Differential and Diagnostic HierarchyNov 2025 · 4 points
- Understanding Anxiety, GAD, and Treatments of AnxietyJun 2025 · 2 points
- Treating Borderline Personality Effectively aka How To Be A Good Psychiatrist Through GPMMay 2025 · 1 point
- PTSD Medications: Integrating Pharmacotherapy, Therapy, and the Treatment Frame | Episode 22Apr 2025 · 40 points
- Understanding Trauma and PTSD, Diagnosis and Dissociation | Episode 21Apr 2025 · 47 points
- Beyond Medications: The Best Lifestyle Treatments for Mental HealthFeb 2025 · 1 point
- Treating Depression: Practical Tips & Pearls for Anti-Depressant MedicationsJan 2025 · 1 point
- Insomnia and Sleep Medications in PsychiatryDec 2024 · 5 points
Every point above is something said on the Psychofarm podcast, with the words as spoken and a link to the moment in the episode. It is education, not medical advice, and an episode reflects what we thought when we recorded it.